abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	VNAMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	SMVSGRSPAYADSVKG	50 - 65	16
HFR3	RFTISRDNAENTVYLQMNSLKPEDTAVYYCNI	66 - 97	32
CDR-H3	KGEYYSRSQYNV	98 - 109	12
HFR4	WGQGTQVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSVN---	26 - 32	7
	AbM	GSIFSVNAMG	26 - 35	10
	Kabat	-----VNAMG	31 - 35	5
	Contact	----SVNAMG	30 - 35	6
	IMGT	GSIFSVNA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKQRELVASM	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAS-	34 - 50	17
CDR-H2	Chothia	-----VSGRS---------	52 - 56	5
	AbM	---SMVSGRSPA-------	50 - 58	9
	Kabat	---SMVSGRSPAYADSVKG	50 - 65	16
	Contact	LVASMVSGRSPA-------	47 - 58	12
	IMGT	----MVSGRSP--------	51 - 57	7
HFR3	Chothia	PAYADSVKGRFTISRDNAENTVYLQMNSLKPEDTAVYYCNI	57 - 97	41
	AbM	--YADSVKGRFTISRDNAENTVYLQMNSLKPEDTAVYYCNI	59 - 97	39
	Kabat	---------RFTISRDNAENTVYLQMNSLKPEDTAVYYCNI	66 - 97	32
	Contact	--YADSVKGRFTISRDNAENTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-AYADSVKGRFTISRDNAENTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--KGEYYSRSQYNV	98 - 109	12
	AbM	--KGEYYSRSQYNV	98 - 109	12
	Kabat	--KGEYYSRSQYNV	98 - 109	12
	Contact	NIKGEYYSRSQYN-	96 - 108	13
	IMGT	NIKGEYYSRSQYNV	96 - 109	14
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	VWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	ARG41576.1
Source	abYsis-EMBL-IG KY704035 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGSIFSVNAMGWYRQAPGKQRELVASMVSGRSPAYA
DSVKGRFTISRDNAENTVYLQMNSLKPEDTAVYYCNIKGEYYSRSQYNVWGQGTQVTVSS

DNA Sequence:

gaagtgcagttagtggagtccgggggggggttagttcagccgggtggctctcttcgttta
tcttgtgccgcatccggcagtattttcagcgttaatgccatgggatggtatcgtcaggca
ccgggcaaacagcgagaacttgtagcctctatggtgtcgggccgttcgccagcgtatgca
gattcagtaaaaggtcggttcacgatctcccgggataatgctgagaataccgtatatctg
cagatgaattctctcaaaccggaggacaccgcggtttactattgcaacataaaaggagaa
tattattcacgctcacaatacaatgtgtggggccagggtactcaggtcacggtatcaagc

Data Source:

Alignment settings:

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