abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
CDR-H1	GDTMG	31 - 35	5
HFR2	WFLQAPGKEREFVA	36 - 49	14
CDR-H2	GINWSSRSTNYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNTLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GPPSPYIYSRPDLYTY	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRSF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRSFSGD---	26 - 32	7
	AbM	GRSFSGDTMG	26 - 35	10
	Kabat	-----GDTMG	31 - 35	5
	Contact	----SGDTMG	30 - 35	6
	IMGT	GRSFSGDT--	26 - 33	8
HFR2	Chothia	TMGWFLQAPGKEREFVAGI	33 - 51	19
	AbM	---WFLQAPGKEREFVA--	36 - 49	14
	Kabat	---WFLQAPGKEREFVA--	36 - 49	14
	Contact	---WFLQAPGKERE-----	36 - 46	11
	IMGT	-MGWFLQAPGKEREFVAG-	34 - 50	17
CDR-H2	Chothia	-----NWSSRS---------	52 - 57	6
	AbM	---GINWSSRSTN-------	50 - 59	10
	Kabat	---GINWSSRSTNYADSVKG	50 - 66	17
	Contact	FVAGINWSSRSTN-------	47 - 59	13
	IMGT	----INWSSRST--------	51 - 58	8
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNTLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNTLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNTLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNTLKPEDTAVYYC--	60 - 96	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNTLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GPPSPYIYSRPDLYTY	99 - 114	16
	AbM	--GPPSPYIYSRPDLYTY	99 - 114	16
	Kabat	--GPPSPYIYSRPDLYTY	99 - 114	16
	Contact	AAGPPSPYIYSRPDLYT-	97 - 113	17
	IMGT	AAGPPSPYIYSRPDLYTY	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	ARG41577.1
Source	abYsis-EMBL-IG KY704036 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRSFSGDTMGWFLQAPGKEREFVAGINWSSRSTNY
ADSVKGRFTISRDNAKNTVYLQMNTLKPEDTAVYYCAAGPPSPYIYSRPDLYTYWGQGTQ
VTVSS

DNA Sequence:

gaagtccagttagtagaatcaggcggtggattagtacaggcaggtggttcgcttcgcctg
agctgcgccgccagtggtcgcagttttagtggtgatactatgggatggtttttacaagcc
cctggtaaggaaagagaattcgtagcagggataaattggagctcgcgcagtactaactac
gctgactccgttaaaggccggtttaccatttcacgcgataacgctaaaaataccgtgtat
cttcagatgaacaccttaaaacccgaagatactgcggtctactattgcgctgcgggtccg
ccttcaccatatatctactcccgcccggatttgtacacctattgggggcagggtacgcaa
gtcacagtttccagc

Data Source:

Alignment settings:

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