abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGSVQAGGSLRLSCAASGR	1 - 27	27
CDR-H1	VAMG	28 - 31	4
HFR2	WFRQAPGKEREFVA	32 - 45	14
CDR-H2	AISASGGSSSYADSVKG	46 - 62	17
HFR3	RFTISRDSAKSTVYLQMNSLEPEDTAVYYCAA	63 - 94	32
CDR-H3	RARTLGWVSADVSAYDY	95 - 111	17
HFR4	WGQGTQVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGSVQAGGSLRLSCAAS--	1 - 25	25
	AbM	EVQLVESGGGSVQAGGSLRLSCAAS--	1 - 25	25
	Kabat	EVQLVESGGGSVQAGGSLRLSCAASGR	1 - 27	27
	Contact	EVQLVESGGGSVQAGGSLRLSCAASGR	1 - 27	27
	IMGT	EVQLVESGGGSVQAGGSLRLSCAAS--	1 - 25	25
CDR-H1	Chothia	GRV---	26 - 28	3
	AbM	GRVAMG	26 - 31	6
	Kabat	--VAMG	28 - 31	4
	Contact	--VAMG	28 - 31	4
	IMGT	GRVA--	26 - 29	4
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	29 - 47	19
	AbM	---WFRQAPGKEREFVA--	32 - 45	14
	Kabat	---WFRQAPGKEREFVA--	32 - 45	14
	Contact	---WFRQAPGKERE-----	32 - 42	11
	IMGT	-MGWFRQAPGKEREFVAA-	30 - 46	17
CDR-H2	Chothia	-----SASGGS---------	48 - 53	6
	AbM	---AISASGGSSS-------	46 - 55	10
	Kabat	---AISASGGSSSYADSVKG	46 - 62	17
	Contact	FVAAISASGGSSS-------	43 - 55	13
	IMGT	----ISASGGSS--------	47 - 54	8
HFR3	Chothia	SSYADSVKGRFTISRDSAKSTVYLQMNSLEPEDTAVYYCAA	54 - 94	41
	AbM	--YADSVKGRFTISRDSAKSTVYLQMNSLEPEDTAVYYCAA	56 - 94	39
	Kabat	---------RFTISRDSAKSTVYLQMNSLEPEDTAVYYCAA	63 - 94	32
	Contact	--YADSVKGRFTISRDSAKSTVYLQMNSLEPEDTAVYYC--	56 - 92	37
	IMGT	-SYADSVKGRFTISRDSAKSTVYLQMNSLEPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--RARTLGWVSADVSAYDY	95 - 111	17
	AbM	--RARTLGWVSADVSAYDY	95 - 111	17
	Kabat	--RARTLGWVSADVSAYDY	95 - 111	17
	Contact	AARARTLGWVSADVSAYD-	93 - 110	18
	IMGT	AARARTLGWVSADVSAYDY	93 - 111	19
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	ARG41578.1
Source	abYsis-EMBL-IG KY704037 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGSVQAGGSLRLSCAASGRVAMGWFRQAPGKEREFVAAISASGGSSSYADSV
KGRFTISRDSAKSTVYLQMNSLEPEDTAVYYCAARARTLGWVSADVSAYDYWGQGTQVTV
SS

DNA Sequence:

gaagtacagctggtggaatctggtgggggctctgttcaagccggcggctctttgcggtta
tcctgtgcggctagcgggagagtcgcaatgggttggttccgccaggcacctggcaaggaa
agggaatttgtagctgctatctcggcgtcgggtggttccagcagttacgcggattcagta
aaaggacgatttaccatatcccgtgattcagctaagtcaacagtatacctgcaaatgaat
agtctcgaacctgaagatactgcagtctattattgcgcggcccgcgctcgtacactgggt
tgggtgtcagccgatgtttctgcttacgattattggggccagggaacacaggtcactgtt
agttcc

Data Source:

Alignment settings:

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