abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCASSGIAFR	1 - 30	30
CDR-H1	LRTMD	31 - 35	5
HFR2	WYRQAPGNQREWVA	36 - 49	14
CDR-H2	TITSDYSTDYADSVKG	50 - 65	16
HFR3	RFTISRDNAQNTVYLQMNSLKPEDTAVYYCHA	66 - 97	32
CDR-H3	GGVV	98 - 101	4
HFR4	WGQGTLVTVSS	102 - 112	11
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCASS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCASS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCASSGIAFR	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCASSGIAF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCASS-----	1 - 25	25
CDR-H1	Chothia	GIAFRLR---	26 - 32	7
	AbM	GIAFRLRTMD	26 - 35	10
	Kabat	-----LRTMD	31 - 35	5
	Contact	----RLRTMD	30 - 35	6
	IMGT	GIAFRLRT--	26 - 33	8
HFR2	Chothia	TMDWYRQAPGNQREWVATI	33 - 51	19
	AbM	---WYRQAPGNQREWVA--	36 - 49	14
	Kabat	---WYRQAPGNQREWVA--	36 - 49	14
	Contact	---WYRQAPGNQRE-----	36 - 46	11
	IMGT	-MDWYRQAPGNQREWVAT-	34 - 50	17
CDR-H2	Chothia	-----TSDYS---------	52 - 56	5
	AbM	---TITSDYSTD-------	50 - 58	9
	Kabat	---TITSDYSTDYADSVKG	50 - 65	16
	Contact	WVATITSDYSTD-------	47 - 58	12
	IMGT	----ITSDYST--------	51 - 57	7
HFR3	Chothia	TDYADSVKGRFTISRDNAQNTVYLQMNSLKPEDTAVYYCHA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAQNTVYLQMNSLKPEDTAVYYCHA	59 - 97	39
	Kabat	---------RFTISRDNAQNTVYLQMNSLKPEDTAVYYCHA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAQNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-DYADSVKGRFTISRDNAQNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--GGVV	98 - 101	4
	AbM	--GGVV	98 - 101	4
	Kabat	--GGVV	98 - 101	4
	Contact	HAGGV-	96 - 100	5
	IMGT	HAGGVV	96 - 101	6
HFR4	Chothia	-WGQGTLVTVSS	102 - 112	11
	AbM	-WGQGTLVTVSS	102 - 112	11
	Kabat	-WGQGTLVTVSS	102 - 112	11
	Contact	VWGQGTLVTVSS	101 - 112	12
	IMGT	-WGQGTLVTVSS	102 - 112	11

Accession & Annotations

Accession	ARG41579.1
Source	abYsis-EMBL-IG KY704038 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCASSGIAFRLRTMDWYRQAPGNQREWVATITSDYSTDYA
DSVKGRFTISRDNAQNTVYLQMNSLKPEDTAVYYCHAGGVVWGQGTLVTVSS

DNA Sequence:

gaagtgcagttagtggaaagcggagggggattagtgcaggctggtggttctttaaggctg
tcttgtgcgagttctggtatcgcattcaggttacgtacgatggactggtacagacaagcg
cctggtaaccaacgtgaatgggtggcaacaataactagcgattatagcacggactatgcg
gattcagtaaaaggaaggtttacaatttctcgcgataatgcccagaatacggtctacctt
caaatgaatagccttaaaccggaagatactgctgtatactactgccatgccggaggggtc
gtttggggacaaggtaccttagtgactgtgagctct

Data Source:

Alignment settings:

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