abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFAFS	1 - 30	30
CDR-H1	RYWMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	AISSSGSSTDYVDSVKG	50 - 66	17
HFR3	RFTVSRDNAKNTLYLQMNGLKSEDTAIYYCAK	67 - 98	32
CDR-H3	DTRQFIRSNYDN	99 - 110	12
HFR4	GGQGTLVTVSS	111 - 121	11
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFAFS	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFAF-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFAFSRY---	26 - 32	7
	AbM	GFAFSRYWMY	26 - 35	10
	Kabat	-----RYWMY	31 - 35	5
	Contact	----SRYWMY	30 - 35	6
	IMGT	GFAFSRYW--	26 - 33	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSAI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSA-	34 - 50	17
CDR-H2	Chothia	-----SSSGSS---------	52 - 57	6
	AbM	---AISSSGSSTD-------	50 - 59	10
	Kabat	---AISSSGSSTDYVDSVKG	50 - 66	17
	Contact	WVSAISSSGSSTD-------	47 - 59	13
	IMGT	----ISSSGSST--------	51 - 58	8
HFR3	Chothia	TDYVDSVKGRFTVSRDNAKNTLYLQMNGLKSEDTAIYYCAK	58 - 98	41
	AbM	--YVDSVKGRFTVSRDNAKNTLYLQMNGLKSEDTAIYYCAK	60 - 98	39
	Kabat	---------RFTVSRDNAKNTLYLQMNGLKSEDTAIYYCAK	67 - 98	32
	Contact	--YVDSVKGRFTVSRDNAKNTLYLQMNGLKSEDTAIYYC--	60 - 96	37
	IMGT	-DYVDSVKGRFTVSRDNAKNTLYLQMNGLKSEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--DTRQFIRSNYDN	99 - 110	12
	AbM	--DTRQFIRSNYDN	99 - 110	12
	Kabat	--DTRQFIRSNYDN	99 - 110	12
	Contact	AKDTRQFIRSNYD-	97 - 109	13
	IMGT	AKDTRQFIRSNYDN	97 - 110	14
HFR4	Chothia	-GGQGTLVTVSS	111 - 121	11
	AbM	-GGQGTLVTVSS	111 - 121	11
	Kabat	-GGQGTLVTVSS	111 - 121	11
	Contact	NGGQGTLVTVSS	110 - 121	12
	IMGT	-GGQGTLVTVSS	111 - 121	11

Accession & Annotations

Accession	ARG41581.1
Source	abYsis-EMBL-IG KY704040 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFAFSRYWMYWVRQAPGKGLEWVSAISSSGSSTDY
VDSVKGRFTVSRDNAKNTLYLQMNGLKSEDTAIYYCAKDTRQFIRSNYDNGGQGTLVTVS
S

DNA Sequence:

gaagttcagctggtggagtcgggaggtggacttgtccaacctggggggtctctgagactc
tcgtgtgccgcttccggttttgcttttagtcgttattggatgtattgggtgaggcaggcc
cctggtaaaggcttagaatgggttagcgccatatcaagcagtgggtcatctacagattat
gtagattccgtcaaaggtcgctttactgtttctcgcgacaacgcgaaaaacacactctat
cttcagatgaatgggttgaaatcggaggatacggccatttattattgtgcgaaggacact
cgccaatttattcgatctaattacgacaatggtggccaggggacacttgtcacagttagt
tct

Data Source:

Alignment settings:

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