abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGVVQTGGSLRLSCAASGR	1 - 27	27
CDR-H1	YAMG	28 - 31	4
HFR2	WFRQVSGKEREFVA	32 - 45	14
CDR-H2	FISASGGSTYYADSVKG	46 - 62	17
HFR3	RFTISRDNAKTTLAYLQMISLKPEDTAVYYCAT	63 - 95	33
CDR-H3	SGGIFRGLYYDTRNYNY	96 - 112	17
HFR4	WGQGTLVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGVVQTGGSLRLSCAAS--	1 - 25	25
	AbM	EVQLVESGGGVVQTGGSLRLSCAAS--	1 - 25	25
	Kabat	EVQLVESGGGVVQTGGSLRLSCAASGR	1 - 27	27
	Contact	EVQLVESGGGVVQTGGSLRLSCAASGR	1 - 27	27
	IMGT	EVQLVESGGGVVQTGGSLRLSCAAS--	1 - 25	25
CDR-H1	Chothia	GRY---	26 - 28	3
	AbM	GRYAMG	26 - 31	6
	Kabat	--YAMG	28 - 31	4
	Contact	--YAMG	28 - 31	4
	IMGT	GRYA--	26 - 29	4
HFR2	Chothia	AMGWFRQVSGKEREFVAFI	29 - 47	19
	AbM	---WFRQVSGKEREFVA--	32 - 45	14
	Kabat	---WFRQVSGKEREFVA--	32 - 45	14
	Contact	---WFRQVSGKERE-----	32 - 42	11
	IMGT	-MGWFRQVSGKEREFVAF-	30 - 46	17
CDR-H2	Chothia	-----SASGGS---------	48 - 53	6
	AbM	---FISASGGSTY-------	46 - 55	10
	Kabat	---FISASGGSTYYADSVKG	46 - 62	17
	Contact	FVAFISASGGSTY-------	43 - 55	13
	IMGT	----ISASGGST--------	47 - 54	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKTTLAYLQMISLKPEDTAVYYCAT	54 - 95	42
	AbM	--YADSVKGRFTISRDNAKTTLAYLQMISLKPEDTAVYYCAT	56 - 95	40
	Kabat	---------RFTISRDNAKTTLAYLQMISLKPEDTAVYYCAT	63 - 95	33
	Contact	--YADSVKGRFTISRDNAKTTLAYLQMISLKPEDTAVYYC--	56 - 93	38
	IMGT	-YYADSVKGRFTISRDNAKTTLAYLQMISLKPEDTAVYYC--	55 - 93	39
CDR-H3	Chothia	--SGGIFRGLYYDTRNYNY	96 - 112	17
	AbM	--SGGIFRGLYYDTRNYNY	96 - 112	17
	Kabat	--SGGIFRGLYYDTRNYNY	96 - 112	17
	Contact	ATSGGIFRGLYYDTRNYN-	94 - 111	18
	IMGT	ATSGGIFRGLYYDTRNYNY	94 - 112	19
HFR4	Chothia	-WGQGTLVTVSS	113 - 123	11
	AbM	-WGQGTLVTVSS	113 - 123	11
	Kabat	-WGQGTLVTVSS	113 - 123	11
	Contact	YWGQGTLVTVSS	112 - 123	12
	IMGT	-WGQGTLVTVSS	113 - 123	11

Accession & Annotations

Accession	ARG41590.1
Source	abYsis-EMBL-IG KY704049 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGVVQTGGSLRLSCAASGRYAMGWFRQVSGKEREFVAFISASGGSTYYADSV
KGRFTISRDNAKTTLAYLQMISLKPEDTAVYYCATSGGIFRGLYYDTRNYNYWGQGTLVT
VSS

DNA Sequence:

gaggtccagttagtcgaatccggtggcggcgtagtgcaaaccggcggatcacttcgcctg
tcatgcgcagcgtcaggaagatatgcgatggggtggtttcgtcaagtttctggtaaggaa
cgagagtttgtcgcttttatcagcgcatcagggggttcgacgtactatgcggactcagtg
aaaggccgttttaccataagtcgtgataacgctaaaacgaccctagcatatcttcagatg
attagcctgaaacctgaagacaccgctgtttattattgtgcaacgtctggtggtatcttc
cgcggactgtactacgatacccgtaactataactactggggtcagggcaccctggtgact
gtatcatca

Data Source:

Alignment settings:

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