abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFAFS	1 - 30	30
CDR-H1	YYYMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	RISPGGGTTYYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLNSEDTAVYYCAK	67 - 98	32
CDR-H3	DNRRLIDSGAYDY	99 - 111	13
HFR4	RGQGTLVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFAFS	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFAF-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFAFSYY---	26 - 32	7
	AbM	GFAFSYYYMY	26 - 35	10
	Kabat	-----YYYMY	31 - 35	5
	Contact	----SYYYMY	30 - 35	6
	IMGT	GFAFSYYY--	26 - 33	8
HFR2	Chothia	YMYWVRQAPGKGLEWVSRI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSR-	34 - 50	17
CDR-H2	Chothia	-----SPGGGT---------	52 - 57	6
	AbM	---RISPGGGTTY-------	50 - 59	10
	Kabat	---RISPGGGTTYYADSVKG	50 - 66	17
	Contact	WVSRISPGGGTTY-------	47 - 59	13
	IMGT	----ISPGGGTT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTLYLQMNSLNSEDTAVYYCAK	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLNSEDTAVYYCAK	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLNSEDTAVYYCAK	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLNSEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAKNTLYLQMNSLNSEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DNRRLIDSGAYDY	99 - 111	13
	AbM	--DNRRLIDSGAYDY	99 - 111	13
	Kabat	--DNRRLIDSGAYDY	99 - 111	13
	Contact	AKDNRRLIDSGAYD-	97 - 110	14
	IMGT	AKDNRRLIDSGAYDY	97 - 111	15
HFR4	Chothia	-RGQGTLVTVSS	112 - 122	11
	AbM	-RGQGTLVTVSS	112 - 122	11
	Kabat	-RGQGTLVTVSS	112 - 122	11
	Contact	YRGQGTLVTVSS	111 - 122	12
	IMGT	-RGQGTLVTVSS	112 - 122	11

Accession & Annotations

Accession	ARG41592.1
Source	abYsis-EMBL-IG KY704051 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFAFSYYYMYWVRQAPGKGLEWVSRISPGGGTTYY
ADSVKGRFTISRDNAKNTLYLQMNSLNSEDTAVYYCAKDNRRLIDSGAYDYRGQGTLVTV
SS

DNA Sequence:

gaggtccaattggtcgaaagcggcggtggacttgttcaaccaggaggttcgcttcgactt
agctgcgctgcaagcggttttgcgttttcttattattacatgtactgggtacgccaggca
ccagggaaaggactggaatgggtaagtcgtatctctccaggaggcggcaccacttactac
gcggactcagtgaaaggtagatttaccattagtagagacaacgcaaaaaacactctgtat
cttcagatgaatagtctgaactcagaagacaccgcggtctattattgtgcgaaagataat
aggcgccttattgattccggcgcatatgattatcgtggacaaggtactttagttacagtg
agctct

Data Source:

Alignment settings:

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