abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGDSLRLSCAASGRTFS	1 - 30	30
CDR-H1	IYSMG	31 - 35	5
HFR2	WFRQATGKEREFVA	36 - 49	14
CDR-H2	AIRWSGTRTYYADSVKG	50 - 66	17
HFR3	RFTISGDIAKNTVYLQMNNLKPEDTAVYSCAA	67 - 98	32
CDR-H3	GGSRGYVAAPDRWDY	99 - 113	15
HFR4	WGQGTLVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGDSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGDSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGDSLRLSCAASGRTFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGDSLRLSCAASGRTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGDSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSIY---	26 - 32	7
	AbM	GRTFSIYSMG	26 - 35	10
	Kabat	-----IYSMG	31 - 35	5
	Contact	----SIYSMG	30 - 35	6
	IMGT	GRTFSIYS--	26 - 33	8
HFR2	Chothia	SMGWFRQATGKEREFVAAI	33 - 51	19
	AbM	---WFRQATGKEREFVA--	36 - 49	14
	Kabat	---WFRQATGKEREFVA--	36 - 49	14
	Contact	---WFRQATGKERE-----	36 - 46	11
	IMGT	-MGWFRQATGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----RWSGTR---------	52 - 57	6
	AbM	---AIRWSGTRTY-------	50 - 59	10
	Kabat	---AIRWSGTRTYYADSVKG	50 - 66	17
	Contact	FVAAIRWSGTRTY-------	47 - 59	13
	IMGT	----IRWSGTRT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISGDIAKNTVYLQMNNLKPEDTAVYSCAA	58 - 98	41
	AbM	--YADSVKGRFTISGDIAKNTVYLQMNNLKPEDTAVYSCAA	60 - 98	39
	Kabat	---------RFTISGDIAKNTVYLQMNNLKPEDTAVYSCAA	67 - 98	32
	Contact	--YADSVKGRFTISGDIAKNTVYLQMNNLKPEDTAVYSC--	60 - 96	37
	IMGT	-YYADSVKGRFTISGDIAKNTVYLQMNNLKPEDTAVYSC--	59 - 96	38
CDR-H3	Chothia	--GGSRGYVAAPDRWDY	99 - 113	15
	AbM	--GGSRGYVAAPDRWDY	99 - 113	15
	Kabat	--GGSRGYVAAPDRWDY	99 - 113	15
	Contact	AAGGSRGYVAAPDRWD-	97 - 112	16
	IMGT	AAGGSRGYVAAPDRWDY	97 - 113	17
HFR4	Chothia	-WGQGTLVTVSS	114 - 124	11
	AbM	-WGQGTLVTVSS	114 - 124	11
	Kabat	-WGQGTLVTVSS	114 - 124	11
	Contact	YWGQGTLVTVSS	113 - 124	12
	IMGT	-WGQGTLVTVSS	114 - 124	11

Accession & Annotations

Accession	ARG41594.1
Source	abYsis-EMBL-IG KY704053 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGDSLRLSCAASGRTFSIYSMGWFRQATGKEREFVAAIRWSGTRTYY
ADSVKGRFTISGDIAKNTVYLQMNNLKPEDTAVYSCAAGGSRGYVAAPDRWDYWGQGTLV
TVSS

DNA Sequence:

gaggtccaactcgttgagtcaggaggtggcctggtgcaagccggtgactcgctgagactg
agttgcgctgcgtctggacggacattttccatttactctatgggatggttccgccaagct
acaggcaaagaacgtgaatttgtcgcggctattcgatggtcaggaacccgtacatactac
gccgattcagtgaaaggtcgctttactatttcgggcgacatcgccaaaaacaccgtctac
ttgcagatgaacaatctgaaaccggaggacactgctgtgtattcctgtgctgctggcggt
tctcgtggttacgtcgctgcgcctgatcgatgggattattggggacaaggtacactcgtt
actgtttctagc

Data Source:

Alignment settings:

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