abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQTGGSLRLSCAASGIYFR	1 - 30	30
CDR-H1	LYTMG	31 - 35	5
HFR2	WYRQAPGNQRELVA	36 - 49	14
CDR-H2	LITSTRSTHYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	HNGQGDF	98 - 104	7
HFR4	WGQGTLVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQTGGSLRLSCAASGIYFR	1 - 30	30
	Contact	EVQLVESGGGLVQTGGSLRLSCAASGIYF-	1 - 29	29
	IMGT	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GIYFRLY---	26 - 32	7
	AbM	GIYFRLYTMG	26 - 35	10
	Kabat	-----LYTMG	31 - 35	5
	Contact	----RLYTMG	30 - 35	6
	IMGT	GIYFRLYT--	26 - 33	8
HFR2	Chothia	TMGWYRQAPGNQRELVALI	33 - 51	19
	AbM	---WYRQAPGNQRELVA--	36 - 49	14
	Kabat	---WYRQAPGNQRELVA--	36 - 49	14
	Contact	---WYRQAPGNQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGNQRELVAL-	34 - 50	17
CDR-H2	Chothia	-----TSTRS---------	52 - 56	5
	AbM	---LITSTRSTH-------	50 - 58	9
	Kabat	---LITSTRSTHYADSVKG	50 - 65	16
	Contact	LVALITSTRSTH-------	47 - 58	12
	IMGT	----ITSTRST--------	51 - 57	7
HFR3	Chothia	THYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-HYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--HNGQGDF	98 - 104	7
	AbM	--HNGQGDF	98 - 104	7
	Kabat	--HNGQGDF	98 - 104	7
	Contact	NAHNGQGD-	96 - 103	8
	IMGT	NAHNGQGDF	96 - 104	9
HFR4	Chothia	-WGQGTLVTVSS	105 - 115	11
	AbM	-WGQGTLVTVSS	105 - 115	11
	Kabat	-WGQGTLVTVSS	105 - 115	11
	Contact	FWGQGTLVTVSS	104 - 115	12
	IMGT	-WGQGTLVTVSS	105 - 115	11

Accession & Annotations

Accession	ARG41595.1
Source	abYsis-EMBL-IG KY704054 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQTGGSLRLSCAASGIYFRLYTMGWYRQAPGNQRELVALITSTRSTHYA
DSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCNAHNGQGDFWGQGTLVTVSS

DNA Sequence:

gaggttcaactcgtggaatcgggaggtggcctcgtacaaacgggtggctccttacggctc
tcgtgtgcggcgagcggaatttattttcgcttgtataccatgggttggtatcggcaggca
cctgggaaccaacgagaattagtggctttgatcactagcacaaggagtacccattacgcc
gatagtgtcaaaggtcgtttcacaatttcccgtgacaatgcgaagaatacactttacctg
cagatgaattccttaaaacccgaagatacggcggtgtactattgtaacgcccataacggt
cagggtgatttttggggccagggtactctagtcaccgtgtcctca

Data Source:

Alignment settings:

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