abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGVVQAGGSLRLSCAASGR	1 - 27	27
CDR-H1	YGVG	28 - 31	4
HFR2	WFRQPPGKEREFVS	32 - 45	14
CDR-H2	AVSKSGGSTYYEDSVKG	46 - 62	17
HFR3	RFTISRDGAKNTVYLQMNSLKPEDTAVYYCAA	63 - 94	32
CDR-H3	DGGGYSAYYYYTHQTEYEY	95 - 113	19
HFR4	WGQGTLVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGVVQAGGSLRLSCAAS--	1 - 25	25
	AbM	EVQLVESGGGVVQAGGSLRLSCAAS--	1 - 25	25
	Kabat	EVQLVESGGGVVQAGGSLRLSCAASGR	1 - 27	27
	Contact	EVQLVESGGGVVQAGGSLRLSCAASGR	1 - 27	27
	IMGT	EVQLVESGGGVVQAGGSLRLSCAAS--	1 - 25	25
CDR-H1	Chothia	GRY---	26 - 28	3
	AbM	GRYGVG	26 - 31	6
	Kabat	--YGVG	28 - 31	4
	Contact	--YGVG	28 - 31	4
	IMGT	GRYG--	26 - 29	4
HFR2	Chothia	GVGWFRQPPGKEREFVSAV	29 - 47	19
	AbM	---WFRQPPGKEREFVS--	32 - 45	14
	Kabat	---WFRQPPGKEREFVS--	32 - 45	14
	Contact	---WFRQPPGKERE-----	32 - 42	11
	IMGT	-VGWFRQPPGKEREFVSA-	30 - 46	17
CDR-H2	Chothia	-----SKSGGS---------	48 - 53	6
	AbM	---AVSKSGGSTY-------	46 - 55	10
	Kabat	---AVSKSGGSTYYEDSVKG	46 - 62	17
	Contact	FVSAVSKSGGSTY-------	43 - 55	13
	IMGT	----VSKSGGST--------	47 - 54	8
HFR3	Chothia	TYYEDSVKGRFTISRDGAKNTVYLQMNSLKPEDTAVYYCAA	54 - 94	41
	AbM	--YEDSVKGRFTISRDGAKNTVYLQMNSLKPEDTAVYYCAA	56 - 94	39
	Kabat	---------RFTISRDGAKNTVYLQMNSLKPEDTAVYYCAA	63 - 94	32
	Contact	--YEDSVKGRFTISRDGAKNTVYLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-YYEDSVKGRFTISRDGAKNTVYLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--DGGGYSAYYYYTHQTEYEY	95 - 113	19
	AbM	--DGGGYSAYYYYTHQTEYEY	95 - 113	19
	Kabat	--DGGGYSAYYYYTHQTEYEY	95 - 113	19
	Contact	AADGGGYSAYYYYTHQTEYE-	93 - 112	20
	IMGT	AADGGGYSAYYYYTHQTEYEY	93 - 113	21
HFR4	Chothia	-WGQGTLVTVSS	114 - 124	11
	AbM	-WGQGTLVTVSS	114 - 124	11
	Kabat	-WGQGTLVTVSS	114 - 124	11
	Contact	YWGQGTLVTVSS	113 - 124	12
	IMGT	-WGQGTLVTVSS	114 - 124	11

Accession & Annotations

Accession	ARG41596.1
Source	abYsis-EMBL-IG KY704055 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGVVQAGGSLRLSCAASGRYGVGWFRQPPGKEREFVSAVSKSGGSTYYEDSV
KGRFTISRDGAKNTVYLQMNSLKPEDTAVYYCAADGGGYSAYYYYTHQTEYEYWGQGTLV
TVSS

DNA Sequence:

gaggttcagctcgttgagtccgggggcggggttgtgcaagcaggtggctctcttcgctta
tcctgcgcggcgagtggccggtacggagttggttggttcaggcagcctcccggtaaagaa
cgggaatttgtatctgcggttagtaagtctggcggttctacgtactatgaggattcggtt
aagggtcgtttcacaatcagccgcgacggagcgaaaaatactgtgtacctccagatgaat
agcctgaagcctgaagacacagccgtgtactattgtgcagcagatggtggaggttactca
gcgtattattactatacacatcagaccgaatatgaatattggggacagggcactctagtg
acggtgagtagc

Data Source:

Alignment settings:

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