abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGALVQAGDSLRVSCVASGRTFS	1 - 30	30
CDR-H1	RYAMG	31 - 35	5
HFR2	WFRQAPGKQREFVA	36 - 49	14
CDR-H2	AISWDGDSTSYANSLKG	50 - 66	17
HFR3	RFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	67 - 98	32
CDR-H3	DRGRTTAWTY	99 - 108	10
HFR4	WGEGTLVTVSS	109 - 119	11
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
	AbM	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
	Kabat	EVQLVESGGALVQAGDSLRVSCVASGRTFS	1 - 30	30
	Contact	EVQLVESGGALVQAGDSLRVSCVASGRTF-	1 - 29	29
	IMGT	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSRY---	26 - 32	7
	AbM	GRTFSRYAMG	26 - 35	10
	Kabat	-----RYAMG	31 - 35	5
	Contact	----SRYAMG	30 - 35	6
	IMGT	GRTFSRYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKQREFVAAI	33 - 51	19
	AbM	---WFRQAPGKQREFVA--	36 - 49	14
	Kabat	---WFRQAPGKQREFVA--	36 - 49	14
	Contact	---WFRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWFRQAPGKQREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWDGDS---------	52 - 57	6
	AbM	---AISWDGDSTS-------	50 - 59	10
	Kabat	---AISWDGDSTSYANSLKG	50 - 66	17
	Contact	FVAAISWDGDSTS-------	47 - 59	13
	IMGT	----ISWDGDST--------	51 - 58	8
HFR3	Chothia	TSYANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	58 - 98	41
	AbM	--YANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	67 - 98	32
	Contact	--YANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYC--	60 - 96	37
	IMGT	-SYANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DRGRTTAWTY	99 - 108	10
	AbM	--DRGRTTAWTY	99 - 108	10
	Kabat	--DRGRTTAWTY	99 - 108	10
	Contact	AADRGRTTAWT-	97 - 107	11
	IMGT	AADRGRTTAWTY	97 - 108	12
HFR4	Chothia	-WGEGTLVTVSS	109 - 119	11
	AbM	-WGEGTLVTVSS	109 - 119	11
	Kabat	-WGEGTLVTVSS	109 - 119	11
	Contact	YWGEGTLVTVSS	108 - 119	12
	IMGT	-WGEGTLVTVSS	109 - 119	11

Accession & Annotations

Accession	ARG41598.1
Source	abYsis-EMBL-IG KY704057 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGALVQAGDSLRVSCVASGRTFSRYAMGWFRQAPGKQREFVAAISWDGDSTSY
ANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAADRGRTTAWTYWGEGTLVTVSS

DNA Sequence:

gaggtacagcttgtggaatcaggtggggcgctggtccaagcaggcgatagtctcagagtc
tcgtgtgtagcatctggccgcacattctcgaggtatgcgatggggtggtttcggcaggcc
ccaggcaaacaacgcgagtttgtggcagcgataagctgggacggtgatagcacaagttac
gctaatagcttaaagggtcgttttacaatttctagagacaacgcgaaaaacaccggatac
ttatatatgaactcattgattccggaggataccgcggtttattactgcgcagcggatcgc
ggccgtactaccgcttggacttattggggcgaaggtacactcgtcacagtgtcgtct

Data Source:

Alignment settings:

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