abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAVSNTVFR	1 - 30	30
CDR-H1	LRTMD	31 - 35	5
HFR2	WYRQAPEKRREWVA	36 - 49	14
CDR-H2	TITSDGSTDYVGAVKG	50 - 65	16
HFR3	RFTISRDNAKSTMYLQMNNVKPEDTAVYYCYT	66 - 97	32
CDR-H3	ANF	98 - 100	3
HFR4	WGQGTLVTVSS	101 - 111	11
			111

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAVSNTVFR	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAVSNTVF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
CDR-H1	Chothia	NTVFRLR---	26 - 32	7
	AbM	NTVFRLRTMD	26 - 35	10
	Kabat	-----LRTMD	31 - 35	5
	Contact	----RLRTMD	30 - 35	6
	IMGT	NTVFRLRT--	26 - 33	8
HFR2	Chothia	TMDWYRQAPEKRREWVATI	33 - 51	19
	AbM	---WYRQAPEKRREWVA--	36 - 49	14
	Kabat	---WYRQAPEKRREWVA--	36 - 49	14
	Contact	---WYRQAPEKRRE-----	36 - 46	11
	IMGT	-MDWYRQAPEKRREWVAT-	34 - 50	17
CDR-H2	Chothia	-----TSDGS---------	52 - 56	5
	AbM	---TITSDGSTD-------	50 - 58	9
	Kabat	---TITSDGSTDYVGAVKG	50 - 65	16
	Contact	WVATITSDGSTD-------	47 - 58	12
	IMGT	----ITSDGST--------	51 - 57	7
HFR3	Chothia	TDYVGAVKGRFTISRDNAKSTMYLQMNNVKPEDTAVYYCYT	57 - 97	41
	AbM	--YVGAVKGRFTISRDNAKSTMYLQMNNVKPEDTAVYYCYT	59 - 97	39
	Kabat	---------RFTISRDNAKSTMYLQMNNVKPEDTAVYYCYT	66 - 97	32
	Contact	--YVGAVKGRFTISRDNAKSTMYLQMNNVKPEDTAVYYC--	59 - 95	37
	IMGT	-DYVGAVKGRFTISRDNAKSTMYLQMNNVKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--ANF	98 - 100	3
	AbM	--ANF	98 - 100	3
	Kabat	--ANF	98 - 100	3
	Contact	YTAN-	96 - 99	4
	IMGT	YTANF	96 - 100	5
HFR4	Chothia	-WGQGTLVTVSS	101 - 111	11
	AbM	-WGQGTLVTVSS	101 - 111	11
	Kabat	-WGQGTLVTVSS	101 - 111	11
	Contact	FWGQGTLVTVSS	100 - 111	12
	IMGT	-WGQGTLVTVSS	101 - 111	11

Accession & Annotations

Accession	ARG41606.1
Source	abYsis-EMBL-IG KY704065 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAVSNTVFRLRTMDWYRQAPEKRREWVATITSDGSTDYV
GAVKGRFTISRDNAKSTMYLQMNNVKPEDTAVYYCYTANFWGQGTLVTVSS

DNA Sequence:

gaagtacagctcgtcgaatcaggaggcggtttagtacaagccggtggttcattgcggcta
tcctgcgctgttagtaacaccgtattccgtctgagaaccatggattggtatagacaagca
ccggagaaaagacgcgaatgggttgcgaccataacgtcagacggttccacggattatgtt
ggcgcggtgaagggtcggttcacaatctccagagataatgctaagagcactatgtatctc
cagatgaacaatgttaagccggaggatacagccgtttactactgttatacagcaaacttt
tgggggcaggggacgctcgtcacggttagttca

Data Source:

Alignment settings:

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