abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SHWMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SIAAGDGSAYYADSVKG	50 - 66	17
HFR3	RFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	67 - 98	32
CDR-H3	DRSRIVGSSRRGTQVTVSS	99 - 117	19
HFR4		-	-
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSH---	26 - 32	7
	AbM	GFTFSSHWMY	26 - 35	10
	Kabat	-----SHWMY	31 - 35	5
	Contact	----SSHWMY	30 - 35	6
	IMGT	GFTFSSHW--	26 - 33	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----AAGDGS---------	52 - 57	6
	AbM	---SIAAGDGSAY-------	50 - 59	10
	Kabat	---SIAAGDGSAYYADSVKG	50 - 66	17
	Contact	WVSSIAAGDGSAY-------	47 - 59	13
	IMGT	----IAAGDGSA--------	51 - 58	8
HFR3	Chothia	AYYADSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	58 - 98	41
	AbM	--YADSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	60 - 98	39
	Kabat	---------RFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	67 - 98	32
	Contact	--YADSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYC--	59 - 96	38
CDR-H3	Chothia	--DRSRIVGSSRRGTQVTVSS	99 - 117	19
	AbM	--DRSRIVGSSRRGTQVTVSS	99 - 117	19
	Kabat	--DRSRIVGSSRRGTQVTVSS	99 - 117	19
	Contact	TTDRSRIVGSSRRGTQVTVSS	97 - 117	21
	IMGT	TTDRSRIVGSSRRGTQVTVSS	97 - 117	21
HFR4	Chothia		-	-
	AbM		-	-
	Kabat		-	-
	Contact		-	-
	IMGT		-	-

Accession & Annotations

Accession	AUS94278.1
Source	abYsis-EMBL-IG MF001020 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV01
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSHWMYWVRQAPGKGLEWVSSIAAGDGSAYY
ADSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTTDRSRIVGSSRRGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcatgtgcagcctctggattcaccttcagtagccactggatgtactgggtccgccaggct
ccagggaaggggctggagtgggtgtcaagtattgctgctggtgatggtagcgcttactat
gcagactccgtgaagggccgattcaccatctctaaagacaacgccaagaatatgctgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgaatattactgtacaacagatcga
agtcgtattgtgggtagtagcaggcgggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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