abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SHWMY	31 - 35	5
HFR2	WVRLAPGKGLEWVS	36 - 49	14
CDR-H2	SISFDGDTYYASSVKG	50 - 65	16
HFR3	RFTISRDVAENMLYLQMNSLQPEDTAVYYCAT	66 - 97	32
CDR-H3	DKTGRT	98 - 103	6
HFR4	RGQGTQVTVSS	104 - 114	11
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSH---	26 - 32	7
	AbM	GFTFSSHWMY	26 - 35	10
	Kabat	-----SHWMY	31 - 35	5
	Contact	----SSHWMY	30 - 35	6
	IMGT	GFTFSSHW--	26 - 33	8
HFR2	Chothia	WMYWVRLAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRLAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRLAPGKGLEWVS--	36 - 49	14
	Contact	---WVRLAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRLAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----SFDGD---------	52 - 56	5
	AbM	---SISFDGDTY-------	50 - 58	9
	Kabat	---SISFDGDTYYASSVKG	50 - 65	16
	Contact	WVSSISFDGDTY-------	47 - 58	12
	IMGT	----ISFDGDT--------	51 - 57	7
HFR3	Chothia	TYYASSVKGRFTISRDVAENMLYLQMNSLQPEDTAVYYCAT	57 - 97	41
	AbM	--YASSVKGRFTISRDVAENMLYLQMNSLQPEDTAVYYCAT	59 - 97	39
	Kabat	---------RFTISRDVAENMLYLQMNSLQPEDTAVYYCAT	66 - 97	32
	Contact	--YASSVKGRFTISRDVAENMLYLQMNSLQPEDTAVYYC--	59 - 95	37
	IMGT	-YYASSVKGRFTISRDVAENMLYLQMNSLQPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--DKTGRT	98 - 103	6
	AbM	--DKTGRT	98 - 103	6
	Kabat	--DKTGRT	98 - 103	6
	Contact	ATDKTGR-	96 - 102	7
	IMGT	ATDKTGRT	96 - 103	8
HFR4	Chothia	-RGQGTQVTVSS	104 - 114	11
	AbM	-RGQGTQVTVSS	104 - 114	11
	Kabat	-RGQGTQVTVSS	104 - 114	11
	Contact	TRGQGTQVTVSS	103 - 114	12
	IMGT	-RGQGTQVTVSS	104 - 114	11

Accession & Annotations

Accession	AUS94279.1
Source	abYsis-EMBL-IG MF001021 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV02
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSHWMYWVRLAPGKGLEWVSSISFDGDTYYA
SSVKGRFTISRDVAENMLYLQMNSLQPEDTAVYYCATDKTGRTRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggattcaccttcagtagccactggatgtactgggtccgcttggct
ccagggaaggggctcgagtgggtctctagtattagttttgatggtgacacatactatgca
agctccgtgaagggccgattcaccatctccagagacgtcgccgagaacatgctgtaccta
caaatgaacagtttgcaacctgaggacactgccgtatattactgcgccaccgacaagact
gggcgtactaggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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