abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLAQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	NHYMY	31 - 35	5
HFR2	WVRQAPGKGLEWVA	36 - 49	14
CDR-H2	SIYSDDSATYYADSVKG	50 - 66	17
HFR3	RFTISTDNTKTTLYLQMNSLKSEDTALYYCST	67 - 98	32
CDR-H3	SRDGRK	99 - 104	6
HFR4	RGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLAQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLAQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLAQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLAQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLAQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSNH---	26 - 32	7
	AbM	GFTFSNHYMY	26 - 35	10
	Kabat	-----NHYMY	31 - 35	5
	Contact	----SNHYMY	30 - 35	6
	IMGT	GFTFSNHY--	26 - 33	8
HFR2	Chothia	YMYWVRQAPGKGLEWVASI	33 - 51	19
	AbM	---WVRQAPGKGLEWVA--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVA--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVAS-	34 - 50	17
CDR-H2	Chothia	-----YSDDSA---------	52 - 57	6
	AbM	---SIYSDDSATY-------	50 - 59	10
	Kabat	---SIYSDDSATYYADSVKG	50 - 66	17
	Contact	WVASIYSDDSATY-------	47 - 59	13
	IMGT	----IYSDDSAT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISTDNTKTTLYLQMNSLKSEDTALYYCST	58 - 98	41
	AbM	--YADSVKGRFTISTDNTKTTLYLQMNSLKSEDTALYYCST	60 - 98	39
	Kabat	---------RFTISTDNTKTTLYLQMNSLKSEDTALYYCST	67 - 98	32
	Contact	--YADSVKGRFTISTDNTKTTLYLQMNSLKSEDTALYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISTDNTKTTLYLQMNSLKSEDTALYYC--	59 - 96	38
CDR-H3	Chothia	--SRDGRK	99 - 104	6
	AbM	--SRDGRK	99 - 104	6
	Kabat	--SRDGRK	99 - 104	6
	Contact	STSRDGR-	97 - 103	7
	IMGT	STSRDGRK	97 - 104	8
HFR4	Chothia	-RGQGTQVTVSS	105 - 115	11
	AbM	-RGQGTQVTVSS	105 - 115	11
	Kabat	-RGQGTQVTVSS	105 - 115	11
	Contact	KRGQGTQVTVSS	104 - 115	12
	IMGT	-RGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	AUS94280.1
Source	abYsis-EMBL-IG MF001022 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV03
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLAQPGGSLRLSCAASGFTFSNHYMYWVRQAPGKGLEWVASIYSDDSATYY
ADSVKGRFTISTDNTKTTLYLQMNSLKSEDTALYYCSTSRDGRKRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggcgcagcctggggggtctctgagactc
tcctgtgcagcatctggattcaccttcagtaaccactacatgtactgggtccgccaggct
ccagggaaggggctggagtgggtagccagtatttacagtgatgacagtgccacatactat
gcagactccgtgaagggccgattcaccatctccacagacaacaccaaaaccacactgtat
ctgcaaatgaacagcctgaaatctgaggacacggccctgtattattgtagcacgagcagg
gacgggcggaaacggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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