abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	NHYMY	31 - 35	5
HFR2	WVRQAPGKGLEWVA	36 - 49	14
CDR-H2	SIYSDDSATYYADSVKG	50 - 66	17
HFR3	RFTISTDNTKSTLYLQMNSLKSEDTALYYCST	67 - 98	32
CDR-H3	SRDGRK	99 - 104	6
HFR4	RGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSNH---	26 - 32	7
	AbM	GFTFSNHYMY	26 - 35	10
	Kabat	-----NHYMY	31 - 35	5
	Contact	----SNHYMY	30 - 35	6
	IMGT	GFTFSNHY--	26 - 33	8
HFR2	Chothia	YMYWVRQAPGKGLEWVASI	33 - 51	19
	AbM	---WVRQAPGKGLEWVA--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVA--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVAS-	34 - 50	17
CDR-H2	Chothia	-----YSDDSA---------	52 - 57	6
	AbM	---SIYSDDSATY-------	50 - 59	10
	Kabat	---SIYSDDSATYYADSVKG	50 - 66	17
	Contact	WVASIYSDDSATY-------	47 - 59	13
	IMGT	----IYSDDSAT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISTDNTKSTLYLQMNSLKSEDTALYYCST	58 - 98	41
	AbM	--YADSVKGRFTISTDNTKSTLYLQMNSLKSEDTALYYCST	60 - 98	39
	Kabat	---------RFTISTDNTKSTLYLQMNSLKSEDTALYYCST	67 - 98	32
	Contact	--YADSVKGRFTISTDNTKSTLYLQMNSLKSEDTALYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISTDNTKSTLYLQMNSLKSEDTALYYC--	59 - 96	38
CDR-H3	Chothia	--SRDGRK	99 - 104	6
	AbM	--SRDGRK	99 - 104	6
	Kabat	--SRDGRK	99 - 104	6
	Contact	STSRDGR-	97 - 103	7
	IMGT	STSRDGRK	97 - 104	8
HFR4	Chothia	-RGQGTQVTVSS	105 - 115	11
	AbM	-RGQGTQVTVSS	105 - 115	11
	Kabat	-RGQGTQVTVSS	105 - 115	11
	Contact	KRGQGTQVTVSS	104 - 115	12
	IMGT	-RGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	AUS94282.1
Source	abYsis-EMBL-IG MF001024 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV07
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSNHYMYWVRQAPGKGLEWVASIYSDDSATYY
ADSVKGRFTISTDNTKSTLYLQMNSLKSEDTALYYCSTSRDGRKRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcatctggattcaccttcagtaaccactacatgtactgggtccgccaggct
ccagggaaggggctggagtgggtagccagtatttacagtgatgacagtgccacatactat
gcagactccgtgaagggccgattcaccatctccacagacaacaccaaaagcacactgtat
ctgcaaatgaacagcctgaaatctgaggacacggccctgtattattgtagcacgagcagg
gacgggcggaaacggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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