abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFSFS	1 - 30	30
CDR-H1	SHWMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SISSGDGSPYYDDSVKG	50 - 66	17
HFR3	RFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	67 - 98	32
CDR-H3	DRNRIVGGSRRGTQVTVSS	99 - 117	19
HFR4		-	-
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFSFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFSF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFSFSSH---	26 - 32	7
	AbM	GFSFSSHWMY	26 - 35	10
	Kabat	-----SHWMY	31 - 35	5
	Contact	----SSHWMY	30 - 35	6
	IMGT	GFSFSSHW--	26 - 33	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----SSGDGS---------	52 - 57	6
	AbM	---SISSGDGSPY-------	50 - 59	10
	Kabat	---SISSGDGSPYYDDSVKG	50 - 66	17
	Contact	WVSSISSGDGSPY-------	47 - 59	13
	IMGT	----ISSGDGSP--------	51 - 58	8
HFR3	Chothia	PYYDDSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	58 - 98	41
	AbM	--YDDSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	60 - 98	39
	Kabat	---------RFTISKDNAKNMLYLQMNSLKPEDTAEYYCTT	67 - 98	32
	Contact	--YDDSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYC--	60 - 96	37
	IMGT	-YYDDSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYC--	59 - 96	38
CDR-H3	Chothia	--DRNRIVGGSRRGTQVTVSS	99 - 117	19
	AbM	--DRNRIVGGSRRGTQVTVSS	99 - 117	19
	Kabat	--DRNRIVGGSRRGTQVTVSS	99 - 117	19
	Contact	TTDRNRIVGGSRRGTQVTVSS	97 - 117	21
	IMGT	TTDRNRIVGGSRRGTQVTVSS	97 - 117	21
HFR4	Chothia		-	-
	AbM		-	-
	Kabat		-	-
	Contact		-	-
	IMGT		-	-

Accession & Annotations

Accession	AUS94283.1
Source	abYsis-EMBL-IG MF001025 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV08
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFSFSSHWMYWVRQAPGKGLEWVSSISSGDGSPYY
DDSVKGRFTISKDNAKNMLYLQMNSLKPEDTAEYYCTTDRNRIVGGSRRGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggattcagcttcagtagccactggatgtactgggtccgccaggct
ccagggaaggggctggagtgggtgtcaagtattagttctggtgatggtagcccttactat
gatgactccgtgaagggccgattcaccatctctaaagacaacgccaagaatatgctgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgaatattactgtacaacagatcgg
aaccgtattgtgggtggtagcaggcgggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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