abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SHWMY	31 - 35	5
HFR2	WGRQAPGKGLEWVS	36 - 49	14
CDR-H2	SINSGGDGTYYSDSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTAVYYCTT	67 - 98	32
CDR-H3	YRYCSGGDCP	99 - 108	10
HFR4	RGQGTQVTVSS	109 - 119	11
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSH---	26 - 32	7
	AbM	GFTFSSHWMY	26 - 35	10
	Kabat	-----SHWMY	31 - 35	5
	Contact	----SSHWMY	30 - 35	6
	IMGT	GFTFSSHW--	26 - 33	8
HFR2	Chothia	WMYWGRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WGRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WGRQAPGKGLEWVS--	36 - 49	14
	Contact	---WGRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWGRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----NSGGDG---------	52 - 57	6
	AbM	---SINSGGDGTY-------	50 - 59	10
	Kabat	---SINSGGDGTYYSDSVKG	50 - 66	17
	Contact	WVSSINSGGDGTY-------	47 - 59	13
	IMGT	----INSGGDGT--------	51 - 58	8
HFR3	Chothia	TYYSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCTT	58 - 98	41
	AbM	--YSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCTT	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTAVYYCTT	67 - 98	32
	Contact	--YSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--YRYCSGGDCP	99 - 108	10
	AbM	--YRYCSGGDCP	99 - 108	10
	Kabat	--YRYCSGGDCP	99 - 108	10
	Contact	TTYRYCSGGDC-	97 - 107	11
	IMGT	TTYRYCSGGDCP	97 - 108	12
HFR4	Chothia	-RGQGTQVTVSS	109 - 119	11
	AbM	-RGQGTQVTVSS	109 - 119	11
	Kabat	-RGQGTQVTVSS	109 - 119	11
	Contact	PRGQGTQVTVSS	108 - 119	12
	IMGT	-RGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	AUS94287.1
Source	abYsis-EMBL-IG MF001029 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV13
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSHWMYWGRQAPGKGLEWVSSINSGGDGTYY
SDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCTTYRYCSGGDCPRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggattcaccttcagtagtcactggatgtattggggccgccaggct
ccagggaaggggctcgagtgggtctcaagtattaatagtggcggtgatggcacatactat
tcagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacgctgtat
ctgcaaatgaacagcttgaaacctgaggacactgccgtgtattactgcactacttatcga
tattgtagtggtggtgactgcccccgtggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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