abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFG	1 - 30	30
CDR-H1	SYYLY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SIYTGDSSTYYADSVKG	50 - 66	17
HFR3	RFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	67 - 98	32
CDR-H3	DGEGRV	99 - 104	6
HFR4	RGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFG	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFGSY---	26 - 32	7
	AbM	GFTFGSYYLY	26 - 35	10
	Kabat	-----SYYLY	31 - 35	5
	Contact	----GSYYLY	30 - 35	6
	IMGT	GFTFGSYY--	26 - 33	8
HFR2	Chothia	YLYWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-LYWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----YTGDSS---------	52 - 57	6
	AbM	---SIYTGDSSTY-------	50 - 59	10
	Kabat	---SIYTGDSSTYYADSVKG	50 - 66	17
	Contact	WVSSIYTGDSSTY-------	47 - 59	13
	IMGT	----IYTGDSST--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	60 - 98	39
	Kabat	---------RFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DGEGRV	99 - 104	6
	AbM	--DGEGRV	99 - 104	6
	Kabat	--DGEGRV	99 - 104	6
	Contact	ATDGEGR-	97 - 103	7
	IMGT	ATDGEGRV	97 - 104	8
HFR4	Chothia	-RGQGTQVTVSS	105 - 115	11
	AbM	-RGQGTQVTVSS	105 - 115	11
	Kabat	-RGQGTQVTVSS	105 - 115	11
	Contact	VRGQGTQVTVSS	104 - 115	12
	IMGT	-RGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	AUS94289.1
Source	abYsis-EMBL-IG MF001031 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV20
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFGSYYLYWVRQAPGKGLEWVSSIYTGDSSTYY
ADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCATDGEGRVRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggattcaccttcggtagctactacttgtactgggtccgccaggct
ccagggaaggggctggagtgggtgtccagtatttatactggtgatagtagcacatactat
gcagactccgtgaagggccgattcaccatctctagtgacaacgccaagaacacgctgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgtgtattactgtgccacagacggg
gagggaagggtaagaggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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