abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFSFS	1 - 30	30
CDR-H1	SHWMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SISSGGISTYYADSVKG	50 - 66	17
HFR3	RFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	67 - 98	32
CDR-H3	DSRGDK	99 - 104	6
HFR4	RGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFSFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFSF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFSFSSH---	26 - 32	7
	AbM	GFSFSSHWMY	26 - 35	10
	Kabat	-----SHWMY	31 - 35	5
	Contact	----SSHWMY	30 - 35	6
	IMGT	GFSFSSHW--	26 - 33	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----SSGGIS---------	52 - 57	6
	AbM	---SISSGGISTY-------	50 - 59	10
	Kabat	---SISSGGISTYYADSVKG	50 - 66	17
	Contact	WVSSISSGGISTY-------	47 - 59	13
	IMGT	----ISSGGIST--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	60 - 98	39
	Kabat	---------RFTISSDNAKNTLYLQMNSLKPEDTAVYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DSRGDK	99 - 104	6
	AbM	--DSRGDK	99 - 104	6
	Kabat	--DSRGDK	99 - 104	6
	Contact	ATDSRGD-	97 - 103	7
	IMGT	ATDSRGDK	97 - 104	8
HFR4	Chothia	-RGQGTQVTVSS	105 - 115	11
	AbM	-RGQGTQVTVSS	105 - 115	11
	Kabat	-RGQGTQVTVSS	105 - 115	11
	Contact	KRGQGTQVTVSS	104 - 115	12
	IMGT	-RGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	AUS94290.1
Source	abYsis-EMBL-IG MF001032 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV21
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFSFSSHWMYWVRQAPGKGLEWVSSISSGGISTYY
ADSVKGRFTISSDNAKNTLYLQMNSLKPEDTAVYYCATDSRGDKRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgcgcagcctctggattcagtttcagtagtcattggatgtactgggtccgccaggct
ccagggaaggggctcgagtgggtctcgtctattagtagtggtggtattagcacatactat
gcagactccgtgaagggccgattcaccatctccagcgacaacgccaagaacacgctgtat
ctgcaaatgaacagtttgaaacctgaggacactgccgtgtattactgcgccacggactcg
cgcggggataagaggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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