abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFG	1 - 30	30
CDR-H1	AYYMY	31 - 35	5
HFR2	WFRQAPGKGLEWVS	36 - 49	14
CDR-H2	SIYTGDDTTYYADSVKG	50 - 66	17
HFR3	RFTISQDNAKNTLYLRMNNLKPEDTAVYYCAT	67 - 98	32
CDR-H3	DSSGRV	99 - 104	6
HFR4	RGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFG	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFGAY---	26 - 32	7
	AbM	GFTFGAYYMY	26 - 35	10
	Kabat	-----AYYMY	31 - 35	5
	Contact	----GAYYMY	30 - 35	6
	IMGT	GFTFGAYY--	26 - 33	8
HFR2	Chothia	YMYWFRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WFRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WFRQAPGKGLEWVS--	36 - 49	14
	Contact	---WFRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWFRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----YTGDDT---------	52 - 57	6
	AbM	---SIYTGDDTTY-------	50 - 59	10
	Kabat	---SIYTGDDTTYYADSVKG	50 - 66	17
	Contact	WVSSIYTGDDTTY-------	47 - 59	13
	IMGT	----IYTGDDTT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISQDNAKNTLYLRMNNLKPEDTAVYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISQDNAKNTLYLRMNNLKPEDTAVYYCAT	60 - 98	39
	Kabat	---------RFTISQDNAKNTLYLRMNNLKPEDTAVYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISQDNAKNTLYLRMNNLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISQDNAKNTLYLRMNNLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DSSGRV	99 - 104	6
	AbM	--DSSGRV	99 - 104	6
	Kabat	--DSSGRV	99 - 104	6
	Contact	ATDSSGR-	97 - 103	7
	IMGT	ATDSSGRV	97 - 104	8
HFR4	Chothia	-RGQGTQVTVSS	105 - 115	11
	AbM	-RGQGTQVTVSS	105 - 115	11
	Kabat	-RGQGTQVTVSS	105 - 115	11
	Contact	VRGQGTQVTVSS	104 - 115	12
	IMGT	-RGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	AUS94292.1
Source	abYsis-EMBL-IG MF001034 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV23
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFGAYYMYWFRQAPGKGLEWVSSIYTGDDTTYY
ADSVKGRFTISQDNAKNTLYLRMNNLKPEDTAVYYCATDSSGRVRGQGTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggattcaccttcggtgcctactatatgtactggttccgccaggct
ccagggaaggggctggagtgggtgtccagtatttatactggtgatgatacaacatactat
gcagactccgtgaagggccgattcaccatctcgcaagacaacgccaagaacacgctgtat
ctgcgaatgaacaacctgaaacctgaggacacggccgtgtattactgtgcaacagattcc
tcgggacgagtgaggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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