abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTLS	1 - 30	30
CDR-H1	NYWMY	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SISTSSYTGGSDTYYADSVKG	50 - 70	21
HFR3	RFTTSKDNAKNTLYLQMNSLKPEDTAVYYCAT	71 - 102	32
CDR-H3	GDAGSNYYP	103 - 111	9
HFR4	RGQGTQVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTLS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTL-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTLSNY---	26 - 32	7
	AbM	GFTLSNYWMY	26 - 35	10
	Kabat	-----NYWMY	31 - 35	5
	Contact	----SNYWMY	30 - 35	6
	IMGT	GFTLSNYW--	26 - 33	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----STSSYTGGSD---------	52 - 61	10
	AbM	---SISTSSYTGGSDTY-------	50 - 63	14
	Kabat	---SISTSSYTGGSDTYYADSVKG	50 - 70	21
	Contact	WVSSISTSSYTGGSDTY-------	47 - 63	17
	IMGT	----ISTSSYTGGSDT--------	51 - 62	12
HFR3	Chothia	TYYADSVKGRFTTSKDNAKNTLYLQMNSLKPEDTAVYYCAT	62 - 102	41
	AbM	--YADSVKGRFTTSKDNAKNTLYLQMNSLKPEDTAVYYCAT	64 - 102	39
	Kabat	---------RFTTSKDNAKNTLYLQMNSLKPEDTAVYYCAT	71 - 102	32
	Contact	--YADSVKGRFTTSKDNAKNTLYLQMNSLKPEDTAVYYC--	64 - 100	37
	IMGT	-YYADSVKGRFTTSKDNAKNTLYLQMNSLKPEDTAVYYC--	63 - 100	38
CDR-H3	Chothia	--GDAGSNYYP	103 - 111	9
	AbM	--GDAGSNYYP	103 - 111	9
	Kabat	--GDAGSNYYP	103 - 111	9
	Contact	ATGDAGSNYY-	101 - 110	10
	IMGT	ATGDAGSNYYP	101 - 111	11
HFR4	Chothia	-RGQGTQVTVSS	112 - 122	11
	AbM	-RGQGTQVTVSS	112 - 122	11
	Kabat	-RGQGTQVTVSS	112 - 122	11
	Contact	PRGQGTQVTVSS	111 - 122	12
	IMGT	-RGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	AUS94293.1
Source	abYsis-EMBL-IG MF001035 Submitted 31-JAN-2018 Updated 31-JAN-2018
Name	anti-BBMV nanobody immunoglobulin heavy chain variable region
Clone	NbBBMV25
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Ghannam A., Kumari S., Muyldermans S., Abbady A.Q. 'Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses' Plant Mol. Biol. 87(4-5):355-369(2015). Abbady A.Q. Submitted (27-APR-2017) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTLSNYWMYWVRQAPGKGLEWVSSISTSSYTGGS
DTYYADSVKGRFTTSKDNAKNTLYLQMNSLKPEDTAVYYCATGDAGSNYYPRGQGTQVTV
SS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgctgcctctgggttcaccctcagtaactactggatgtactgggtccgccaggct
ccagggaaggggctggagtgggtgtccagtattagtactagtagctatactggtggtagt
gacacatactatgcagactccgtgaagggccgattcaccacctctaaagacaacgccaag
aacacgctgtatctgcaaatgaacagcctgaaacctgaggacacggccgtgtattactgt
gccacaggcgacgccggtagtaactattacccacggggccaggggacccaggtcaccgtc
tcctca

Data Source:

Alignment settings:

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