abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVRGSLRLSCVASGYSVS	1 - 28	28
CDR-H1	KNSI	29 - 32	4
HFR2	WFRQAPGEREGVA	33 - 45	13
CDR-H2	GINHGGTNLKG	46 - 56	11
HFR3	RFTISDNAKNTVYLQMNTLPEDTAIYYCAA	57 - 86	30
CDR-H3	GSPDPPPLIESVVKY	87 - 101	15
HFR4	WGQGTQVTVSS	102 - 112	11
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVRGSLRLSCVAS-----	1 - 23	23
	AbM	QVQLQESGGGSVRGSLRLSCVAS-----	1 - 23	23
	Kabat	QVQLQESGGGSVRGSLRLSCVASGYSVS	1 - 28	28
	Contact	QVQLQESGGGSVRGSLRLSCVASGYSV-	1 - 27	27
	IMGT	QVQLQESGGGSVRGSLRLSCVAS-----	1 - 23	23
CDR-H1	Chothia	GYSVSK---	24 - 29	6
	AbM	GYSVSKNSI	24 - 32	9
	Kabat	-----KNSI	29 - 32	4
	Contact	----SKNSI	28 - 32	5
	IMGT	GYSVSKN--	24 - 30	7
HFR2	Chothia	NSIWFRQAPGEREGVAGI	30 - 47	18
	AbM	---WFRQAPGEREGVA--	33 - 45	13
	Kabat	---WFRQAPGEREGVA--	33 - 45	13
	Contact	---WFRQAPGERE-----	33 - 42	10
	IMGT	-SIWFRQAPGEREGVAG-	31 - 46	16
CDR-H2	Chothia	-----N--------	48 - 48	1
	AbM	---GINH-------	46 - 49	4
	Kabat	---GINHGGTNLKG	46 - 56	11
	Contact	GVAGINH-------	43 - 49	7
	IMGT	----IN--------	47 - 48	2
HFR3	Chothia	HGGTNLKGRFTISDNAKNTVYLQMNTLPEDTAIYYCAA	49 - 86	38
	AbM	-GGTNLKGRFTISDNAKNTVYLQMNTLPEDTAIYYCAA	50 - 86	37
	Kabat	--------RFTISDNAKNTVYLQMNTLPEDTAIYYCAA	57 - 86	30
	Contact	-GGTNLKGRFTISDNAKNTVYLQMNTLPEDTAIYYC--	50 - 84	35
	IMGT	HGGTNLKGRFTISDNAKNTVYLQMNTLPEDTAIYYC--	49 - 84	36
CDR-H3	Chothia	--GSPDPPPLIESVVKY	87 - 101	15
	AbM	--GSPDPPPLIESVVKY	87 - 101	15
	Kabat	--GSPDPPPLIESVVKY	87 - 101	15
	Contact	AAGSPDPPPLIESVVK-	85 - 100	16
	IMGT	AAGSPDPPPLIESVVKY	85 - 101	17
HFR4	Chothia	-WGQGTQVTVSS	102 - 112	11
	AbM	-WGQGTQVTVSS	102 - 112	11
	Kabat	-WGQGTQVTVSS	102 - 112	11
	Contact	YWGQGTQVTVSS	101 - 112	12
	IMGT	-WGQGTQVTVSS	102 - 112	11

Accession & Annotations

Accession	ASN64746.1
Source	abYsis-EMBL-IG MF280918 Submitted 01-AUG-2017 Updated 01-AUG-2017
Name	immunoglobulin heavy chain variable region
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Behdani M., Zeinali S., Khanahmad H., Karimipour M., Asadzadeh N., Azadmanesh K., Khabiri A., Schoonooghe S., Habibi Anbouhi M., Hassanzadeh-Ghassabeh G., Muyldermans S. 'Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor' Mol. Immunol. 50(1-2):35-41(2012). Behdani M. Submitted (07-JUN-2017) to the INSDC. Venom & Biotherapeutics Molecules Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur St., Tehran 13149857, Iran

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVRGSLRLSCVASGYSVSKNSIWFRQAPGEREGVAGINHGGTNLKGRFTI
SDNAKNTVYLQMNTLPEDTAIYYCAAGSPDPPPLIESVVKYWGQGTQVTVSS

DNA Sequence:

tcaggtgcagctgcaggagtctgggggaggctcggtgcgagggtctctgagactctcctg
tgtagcctctggatactccgtcagtaaaaactccatctggttccgccaggctccagggga
gcgtgagggcgtcgcaggtattaatcatggtggtaccaacttgaagggccgattcaccat
ctccgacaacgccaagaacacggtgtatctgcaaatgaacaccctgcctgaggacacggc
catctattactgtgcggcaggttcccccgatcccccccccctcatagagagtgtcgtaaa
gtactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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