abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	1 - 30	30
CDR-H1	SSAMG	31 - 35	5
HFR2	WYRRAPGKQRELVA	36 - 49	14
CDR-H2	SLTTTGTADYGDFVKG	50 - 65	16
HFR3	RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	66 - 97	32
CDR-H3	DPYGMESLRY	98 - 107	10
HFR4	WGQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQVGGSLRLSCKAS-----	1 - 25	25
	AbM	KVQLQESGGGLVQVGGSLRLSCKAS-----	1 - 25	25
	Kabat	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	1 - 30	30
	Contact	KVQLQESGGGLVQVGGSLRLSCKASGFTF-	1 - 29	29
	IMGT	KVQLQESGGGLVQVGGSLRLSCKAS-----	1 - 25	25
CDR-H1	Chothia	GFTFRSS---	26 - 32	7
	AbM	GFTFRSSAMG	26 - 35	10
	Kabat	-----SSAMG	31 - 35	5
	Contact	----RSSAMG	30 - 35	6
	IMGT	GFTFRSSA--	26 - 33	8
HFR2	Chothia	AMGWYRRAPGKQRELVASL	33 - 51	19
	AbM	---WYRRAPGKQRELVA--	36 - 49	14
	Kabat	---WYRRAPGKQRELVA--	36 - 49	14
	Contact	---WYRRAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRRAPGKQRELVAS-	34 - 50	17
CDR-H2	Chothia	-----TTTGT---------	52 - 56	5
	AbM	---SLTTTGTAD-------	50 - 58	9
	Kabat	---SLTTTGTADYGDFVKG	50 - 65	16
	Contact	LVASLTTTGTAD-------	47 - 58	12
	IMGT	----LTTTGTA--------	51 - 57	7
HFR3	Chothia	ADYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	57 - 97	41
	AbM	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	59 - 97	39
	Kabat	---------RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	66 - 97	32
	Contact	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-DYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--DPYGMESLRY	98 - 107	10
	AbM	--DPYGMESLRY	98 - 107	10
	Kabat	--DPYGMESLRY	98 - 107	10
	Contact	HEDPYGMESLR-	96 - 106	11
	IMGT	HEDPYGMESLRY	96 - 107	12
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	YWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	ATN23971.1
Source	abYsis-EMBL-IG MF780585 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Marburg virus nucleoprotein single domain antibody C
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4w2q_A 4w2q_C 4w2q_E 4w2q_G
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVQLQESGGGLVQVGGSLRLSCKASGFTFRSSAMGWYRRAPGKQRELVASLTTTGTADYG
DFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHEDPYGMESLRYWGQGTQVTVSS

DNA Sequence:

aaggtgcagctgcaggagtctgggggaggcttagtgcaggttggggggtctctgagactc
tcctgtaaagcgtctggatttactttccgatcgtccgccatgggttggtatcgccgggct
ccagggaagcagcgcgagttggtcgcctctctcaccacaactgggaccgcggactatgga
gactttgtgaagggccgattcaccatctcgagagacaacgccgagaacacggtggatctg
catatgaacagcctgaaacctgaggacacggccgtctactactgtcatgaagatccttac
ggaatggaatcccttcgctactggggccaggggacccaagtcacggtctcctcg

Data Source:

Alignment settings:

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