abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLQQSGGGSVQEGGSLRLSCASSGAFFR	1 - 30	30
CDR-H1	AGPMG	31 - 35	5
HFR2	WYRRAPGNERELVA	36 - 49	14
CDR-H2	GISRNGRTIYAPSLKD	50 - 65	16
HFR3	RFTISRDDDNNILYLQMSDLTPGDTAVYYCNL	66 - 97	32
CDR-H3	NVRTAVAGRNDY	98 - 109	12
HFR4	WGQGTQVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLQQSGGGSVQEGGSLRLSCASS-----	1 - 25	25
	AbM	QVKLQQSGGGSVQEGGSLRLSCASS-----	1 - 25	25
	Kabat	QVKLQQSGGGSVQEGGSLRLSCASSGAFFR	1 - 30	30
	Contact	QVKLQQSGGGSVQEGGSLRLSCASSGAFF-	1 - 29	29
	IMGT	QVKLQQSGGGSVQEGGSLRLSCASS-----	1 - 25	25
CDR-H1	Chothia	GAFFRAG---	26 - 32	7
	AbM	GAFFRAGPMG	26 - 35	10
	Kabat	-----AGPMG	31 - 35	5
	Contact	----RAGPMG	30 - 35	6
	IMGT	GAFFRAGP--	26 - 33	8
HFR2	Chothia	PMGWYRRAPGNERELVAGI	33 - 51	19
	AbM	---WYRRAPGNERELVA--	36 - 49	14
	Kabat	---WYRRAPGNERELVA--	36 - 49	14
	Contact	---WYRRAPGNERE-----	36 - 46	11
	IMGT	-MGWYRRAPGNERELVAG-	34 - 50	17
CDR-H2	Chothia	-----SRNGR---------	52 - 56	5
	AbM	---GISRNGRTI-------	50 - 58	9
	Kabat	---GISRNGRTIYAPSLKD	50 - 65	16
	Contact	LVAGISRNGRTI-------	47 - 58	12
	IMGT	----ISRNGRT--------	51 - 57	7
HFR3	Chothia	TIYAPSLKDRFTISRDDDNNILYLQMSDLTPGDTAVYYCNL	57 - 97	41
	AbM	--YAPSLKDRFTISRDDDNNILYLQMSDLTPGDTAVYYCNL	59 - 97	39
	Kabat	---------RFTISRDDDNNILYLQMSDLTPGDTAVYYCNL	66 - 97	32
	Contact	--YAPSLKDRFTISRDDDNNILYLQMSDLTPGDTAVYYC--	59 - 95	37
	IMGT	-IYAPSLKDRFTISRDDDNNILYLQMSDLTPGDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--NVRTAVAGRNDY	98 - 109	12
	AbM	--NVRTAVAGRNDY	98 - 109	12
	Kabat	--NVRTAVAGRNDY	98 - 109	12
	Contact	NLNVRTAVAGRND-	96 - 108	13
	IMGT	NLNVRTAVAGRNDY	96 - 109	14
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	ATN23916.1
Source	abYsis-EMBL-IG MF780587 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Sudan virus nucleoprotein single domain antibody B
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

QVKLQQSGGGSVQEGGSLRLSCASSGAFFRAGPMGWYRRAPGNERELVAGISRNGRTIYA
PSLKDRFTISRDDDNNILYLQMSDLTPGDTAVYYCNLNVRTAVAGRNDYWGQGTQVTVSS

DNA Sequence:

caggtcaaactgcagcagtcagggggaggttcagtgcaggaaggggggtctctgagactc
tcctgtgcatcctccggagcgttctttagagccggtcccatgggttggtaccgccgggct
ccaggaaatgagcgcgagttggtcgcaggtattagtcgtaatggtcgcacaatctatgca
ccctccctgaaggaccggttcaccatctccagagacgatgacaataacatcctgtatctg
caaatgtccgatctgacaccgggggacacggccgtctattactgtaatctaaacgtacgt
acggcagtagccggaagaaatgactactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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