abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVKLQESGGGAVEIGGSLRLSCVASGSAFS	1 - 30	30
CDR-H1	INSMY	31 - 35	5
HFR2	WYRQAPGKVREVVA	36 - 49	14
CDR-H2	MITSAGATTYASSLKD	50 - 65	16
HFR3	RFTISRDNAKNTVYLHMSSLKVEDTAVYYCDA	66 - 97	32
CDR-H3	GGST	98 - 101	4
HFR4	WGQGTQVTVSS	102 - 112	11
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVKLQESGGGAVEIGGSLRLSCVAS-----	1 - 25	25
	AbM	KVKLQESGGGAVEIGGSLRLSCVAS-----	1 - 25	25
	Kabat	KVKLQESGGGAVEIGGSLRLSCVASGSAFS	1 - 30	30
	Contact	KVKLQESGGGAVEIGGSLRLSCVASGSAF-	1 - 29	29
	IMGT	KVKLQESGGGAVEIGGSLRLSCVAS-----	1 - 25	25
CDR-H1	Chothia	GSAFSIN---	26 - 32	7
	AbM	GSAFSINSMY	26 - 35	10
	Kabat	-----INSMY	31 - 35	5
	Contact	----SINSMY	30 - 35	6
	IMGT	GSAFSINS--	26 - 33	8
HFR2	Chothia	SMYWYRQAPGKVREVVAMI	33 - 51	19
	AbM	---WYRQAPGKVREVVA--	36 - 49	14
	Kabat	---WYRQAPGKVREVVA--	36 - 49	14
	Contact	---WYRQAPGKVRE-----	36 - 46	11
	IMGT	-MYWYRQAPGKVREVVAM-	34 - 50	17
CDR-H2	Chothia	-----TSAGA---------	52 - 56	5
	AbM	---MITSAGATT-------	50 - 58	9
	Kabat	---MITSAGATTYASSLKD	50 - 65	16
	Contact	VVAMITSAGATT-------	47 - 58	12
	IMGT	----ITSAGAT--------	51 - 57	7
HFR3	Chothia	TTYASSLKDRFTISRDNAKNTVYLHMSSLKVEDTAVYYCDA	57 - 97	41
	AbM	--YASSLKDRFTISRDNAKNTVYLHMSSLKVEDTAVYYCDA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLHMSSLKVEDTAVYYCDA	66 - 97	32
	Contact	--YASSLKDRFTISRDNAKNTVYLHMSSLKVEDTAVYYC--	59 - 95	37
	IMGT	-TYASSLKDRFTISRDNAKNTVYLHMSSLKVEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--GGST	98 - 101	4
	AbM	--GGST	98 - 101	4
	Kabat	--GGST	98 - 101	4
	Contact	DAGGS-	96 - 100	5
	IMGT	DAGGST	96 - 101	6
HFR4	Chothia	-WGQGTQVTVSS	102 - 112	11
	AbM	-WGQGTQVTVSS	102 - 112	11
	Kabat	-WGQGTQVTVSS	102 - 112	11
	Contact	TWGQGTQVTVSS	101 - 112	12
	IMGT	-WGQGTQVTVSS	102 - 112	11

Accession & Annotations

Accession	ATN23917.1
Source	abYsis-EMBL-IG MF780588 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Ivory Coast virus nucleoprotein single domain antibody A
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVKLQESGGGAVEIGGSLRLSCVASGSAFSINSMYWYRQAPGKVREVVAMITSAGATTYA
SSLKDRFTISRDNAKNTVYLHMSSLKVEDTAVYYCDAGGSTWGQGTQVTVSS

DNA Sequence:

aaggtgaaactgcaggagtctggaggaggcgcagtggagattggggggtctctgagactc
tcctgtgtagcctcgggaagcgccttcagtatcaattccatgtactggtaccgccaggct
ccagggaaggtgcgcgaagtggtcgcaatgattactagcgcaggtgccacaacgtatgcg
agctccttgaaggaccgattcaccatctccagggacaacgccaagaacacggtgtatctg
cacatgagcagcctgaaagtcgaggacacggccgtctattactgtgatgcgggtggtagc
acttggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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