abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVKLQESGGGLVRAGESLTLACAASGHQLY	1 - 30	30
CDR-H1	RPPVT	31 - 35	5
HFR2	WYRRAPGKQRELLA	36 - 49	14
CDR-H2	FITGGGTTIYRDAAKG	50 - 65	16
HFR3	RFTISRDDVKNQVYLQMTNLNPEDTGVYYCGA	66 - 97	32
CDR-H3	GKSAYGGYNY	98 - 107	10
HFR4	YGQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVKLQESGGGLVRAGESLTLACAAS-----	1 - 25	25
	AbM	KVKLQESGGGLVRAGESLTLACAAS-----	1 - 25	25
	Kabat	KVKLQESGGGLVRAGESLTLACAASGHQLY	1 - 30	30
	Contact	KVKLQESGGGLVRAGESLTLACAASGHQL-	1 - 29	29
	IMGT	KVKLQESGGGLVRAGESLTLACAAS-----	1 - 25	25
CDR-H1	Chothia	GHQLYRP---	26 - 32	7
	AbM	GHQLYRPPVT	26 - 35	10
	Kabat	-----RPPVT	31 - 35	5
	Contact	----YRPPVT	30 - 35	6
	IMGT	GHQLYRPP--	26 - 33	8
HFR2	Chothia	PVTWYRRAPGKQRELLAFI	33 - 51	19
	AbM	---WYRRAPGKQRELLA--	36 - 49	14
	Kabat	---WYRRAPGKQRELLA--	36 - 49	14
	Contact	---WYRRAPGKQRE-----	36 - 46	11
	IMGT	-VTWYRRAPGKQRELLAF-	34 - 50	17
CDR-H2	Chothia	-----TGGGT---------	52 - 56	5
	AbM	---FITGGGTTI-------	50 - 58	9
	Kabat	---FITGGGTTIYRDAAKG	50 - 65	16
	Contact	LLAFITGGGTTI-------	47 - 58	12
	IMGT	----ITGGGTT--------	51 - 57	7
HFR3	Chothia	TIYRDAAKGRFTISRDDVKNQVYLQMTNLNPEDTGVYYCGA	57 - 97	41
	AbM	--YRDAAKGRFTISRDDVKNQVYLQMTNLNPEDTGVYYCGA	59 - 97	39
	Kabat	---------RFTISRDDVKNQVYLQMTNLNPEDTGVYYCGA	66 - 97	32
	Contact	--YRDAAKGRFTISRDDVKNQVYLQMTNLNPEDTGVYYC--	59 - 95	37
	IMGT	-IYRDAAKGRFTISRDDVKNQVYLQMTNLNPEDTGVYYC--	58 - 95	38
CDR-H3	Chothia	--GKSAYGGYNY	98 - 107	10
	AbM	--GKSAYGGYNY	98 - 107	10
	Kabat	--GKSAYGGYNY	98 - 107	10
	Contact	GAGKSAYGGYN-	96 - 106	11
	IMGT	GAGKSAYGGYNY	96 - 107	12
HFR4	Chothia	-YGQGTQVTVSS	108 - 118	11
	AbM	-YGQGTQVTVSS	108 - 118	11
	Kabat	-YGQGTQVTVSS	108 - 118	11
	Contact	YYGQGTQVTVSS	107 - 118	12
	IMGT	-YGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	ATN23921.1
Source	abYsis-EMBL-IG MF780592 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Ivory Coast virus nucleoprotein single domain antibody E
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVKLQESGGGLVRAGESLTLACAASGHQLYRPPVTWYRRAPGKQRELLAFITGGGTTIYR
DAAKGRFTISRDDVKNQVYLQMTNLNPEDTGVYYCGAGKSAYGGYNYYGQGTQVTVSS

DNA Sequence:

aaggtcaaactgcaggagtcagggggaggcttagtgcgtgctggcgaatctctgactctc
gcctgtgcggcatctggacatcaactctacagaccgcccgtgacctggtaccgccgggcg
ccgggaaagcagcgcgaattgcttgcatttattactggtgggggtacgacaatctatcga
gatgccgcgaagggccgtttcaccatttccagagacgacgtcaagaatcaagtgtatctg
caaatgaccaatttgaatcctgaggacacaggggtctattactgcggagccggaaaaagc
gcttacgggggctacaactactatggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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