abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQQSGGGVVQAGRSLRLSCTASTDRKL	1 - 30	30
CDR-H1	YTMG	31 - 34	4
HFR2	WYRRAPGQKCELVG	35 - 48	14
CDR-H2	GITVGGDTYYTDPVKG	49 - 64	16
HFR3	RFTISRDNKQNMAWLQMDNLVPEDTAVYYCKI	65 - 96	32
CDR-H3	WGQKTC	97 - 102	6
HFR4	SGRGTQVTVSP	103 - 113	11
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQQSGGGVVQAGRSLRLSCTAS-----	1 - 25	25
	AbM	QVQLQQSGGGVVQAGRSLRLSCTAS-----	1 - 25	25
	Kabat	QVQLQQSGGGVVQAGRSLRLSCTASTDRKL	1 - 30	30
	Contact	QVQLQQSGGGVVQAGRSLRLSCTASTDRK-	1 - 29	29
	IMGT	QVQLQQSGGGVVQAGRSLRLSCTAS-----	1 - 25	25
CDR-H1	Chothia	TDRKLY---	26 - 31	6
	AbM	TDRKLYTMG	26 - 34	9
	Kabat	-----YTMG	31 - 34	4
	Contact	----LYTMG	30 - 34	5
	IMGT	TDRKLYT--	26 - 32	7
HFR2	Chothia	TMGWYRRAPGQKCELVGGI	32 - 50	19
	AbM	---WYRRAPGQKCELVG--	35 - 48	14
	Kabat	---WYRRAPGQKCELVG--	35 - 48	14
	Contact	---WYRRAPGQKCE-----	35 - 45	11
	IMGT	-MGWYRRAPGQKCELVGG-	33 - 49	17
CDR-H2	Chothia	-----TVGGD---------	51 - 55	5
	AbM	---GITVGGDTY-------	49 - 57	9
	Kabat	---GITVGGDTYYTDPVKG	49 - 64	16
	Contact	LVGGITVGGDTY-------	46 - 57	12
	IMGT	----ITVGGDT--------	50 - 56	7
HFR3	Chothia	TYYTDPVKGRFTISRDNKQNMAWLQMDNLVPEDTAVYYCKI	56 - 96	41
	AbM	--YTDPVKGRFTISRDNKQNMAWLQMDNLVPEDTAVYYCKI	58 - 96	39
	Kabat	---------RFTISRDNKQNMAWLQMDNLVPEDTAVYYCKI	65 - 96	32
	Contact	--YTDPVKGRFTISRDNKQNMAWLQMDNLVPEDTAVYYC--	58 - 94	37
	IMGT	-YYTDPVKGRFTISRDNKQNMAWLQMDNLVPEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--WGQKTC	97 - 102	6
	AbM	--WGQKTC	97 - 102	6
	Kabat	--WGQKTC	97 - 102	6
	Contact	KIWGQKT-	95 - 101	7
	IMGT	KIWGQKTC	95 - 102	8
HFR4	Chothia	-SGRGTQVTVSP	103 - 113	11
	AbM	-SGRGTQVTVSP	103 - 113	11
	Kabat	-SGRGTQVTVSP	103 - 113	11
	Contact	CSGRGTQVTVSP	102 - 113	12
	IMGT	-SGRGTQVTVSP	103 - 113	11

Accession & Annotations

Accession	ATN23922.1
Source	abYsis-EMBL-IG MF780593 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Ivory Coast virus nucleoprotein single domain antibody F
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

QVQLQQSGGGVVQAGRSLRLSCTASTDRKLYTMGWYRRAPGQKCELVGGITVGGDTYYTD
PVKGRFTISRDNKQNMAWLQMDNLVPEDTAVYYCKIWGQKTCSGRGTQVTVSP

DNA Sequence:

caggtgcagctgcagcagtctggcggaggcgtggtacaggctgggcggtctttgagactc
tcatgtacagcctcgacagacaggaaactatataccatgggctggtatcgccgggctcct
ggacagaagtgcgaattggtcgggggtattacagtaggtggtgacacttactacacagac
cctgtgaagggccggttcaccatctctagggacaataaacagaacatggcgtggctgcaa
atggacaacctcgtacctgaagatacggccgtctattactgcaaaatatggggccagaag
acctgctcgggccgggggacccaggtcaccgtctcacca

Data Source:

Alignment settings:

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