abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVQLQESGGGLVQAGRSLRLSCAATGITFR	1 - 30	30
CDR-H1	IYAMG	31 - 35	5
HFR2	WYRQVPGKQRELVA	36 - 49	14
CDR-H2	RISSGGSTEYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTLNLQMNSLKPEDTAVYYCHA	66 - 97	32
CDR-H3	LLGNIPH	98 - 104	7
HFR4	WGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQAGRSLRLSCAAT-----	1 - 25	25
	AbM	KVQLQESGGGLVQAGRSLRLSCAAT-----	1 - 25	25
	Kabat	KVQLQESGGGLVQAGRSLRLSCAATGITFR	1 - 30	30
	Contact	KVQLQESGGGLVQAGRSLRLSCAATGITF-	1 - 29	29
	IMGT	KVQLQESGGGLVQAGRSLRLSCAAT-----	1 - 25	25
CDR-H1	Chothia	GITFRIY---	26 - 32	7
	AbM	GITFRIYAMG	26 - 35	10
	Kabat	-----IYAMG	31 - 35	5
	Contact	----RIYAMG	30 - 35	6
	IMGT	GITFRIYA--	26 - 33	8
HFR2	Chothia	AMGWYRQVPGKQRELVARI	33 - 51	19
	AbM	---WYRQVPGKQRELVA--	36 - 49	14
	Kabat	---WYRQVPGKQRELVA--	36 - 49	14
	Contact	---WYRQVPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQVPGKQRELVAR-	34 - 50	17
CDR-H2	Chothia	-----SSGGS---------	52 - 56	5
	AbM	---RISSGGSTE-------	50 - 58	9
	Kabat	---RISSGGSTEYADSVKG	50 - 65	16
	Contact	LVARISSGGSTE-------	47 - 58	12
	IMGT	----ISSGGST--------	51 - 57	7
HFR3	Chothia	TEYADSVKGRFTISRDNAKNTLNLQMNSLKPEDTAVYYCHA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTLNLQMNSLKPEDTAVYYCHA	59 - 97	39
	Kabat	---------RFTISRDNAKNTLNLQMNSLKPEDTAVYYCHA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTLNLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-EYADSVKGRFTISRDNAKNTLNLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--LLGNIPH	98 - 104	7
	AbM	--LLGNIPH	98 - 104	7
	Kabat	--LLGNIPH	98 - 104	7
	Contact	HALLGNIP-	96 - 103	8
	IMGT	HALLGNIPH	96 - 104	9
HFR4	Chothia	-WGQGTQVTVSS	105 - 115	11
	AbM	-WGQGTQVTVSS	105 - 115	11
	Kabat	-WGQGTQVTVSS	105 - 115	11
	Contact	HWGQGTQVTVSS	104 - 115	12
	IMGT	-WGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	ATN23923.1
Source	abYsis-EMBL-IG MF780594 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Reston virus nucleoprotein single domain antibody A
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVQLQESGGGLVQAGRSLRLSCAATGITFRIYAMGWYRQVPGKQRELVARISSGGSTEYA
DSVKGRFTISRDNAKNTLNLQMNSLKPEDTAVYYCHALLGNIPHWGQGTQVTVSS

DNA Sequence:

aaggtgcaactgcaggagtctgggggaggcttggtgcaggctgggaggtctctgagactc
tcctgtgcagccactggaatcaccttcaggatctatgccatgggttggtaccgccaggtt
ccagggaagcagcgcgagttggtcgcacgtattagtagtggtggtagcacagagtatgca
gattccgtgaagggccggttcaccatctccagagacaacgccaagaacacgctcaatctg
caaatgaacagcctgaaacctgaggacacagccgtctattactgccacgctttattgggt
aacattccccactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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