abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVKLQESGGGLVQAGGSLRLSCEASGRTFN	1 - 30	30
CDR-H1	INSMR	31 - 35	5
HFR2	WYRQAPGKQRDWVA	36 - 49	14
CDR-H2	SISSGGSTYYADSVKG	50 - 65	16
HFR3	RFTISRDNAANMVYLQMNDLKPEDTAVYFCTE	66 - 97	32
CDR-H3	GVLNVPSLD	98 - 106	9
HFR4	LGPGTLVVVSA	107 - 117	11
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVKLQESGGGLVQAGGSLRLSCEAS-----	1 - 25	25
	AbM	EVKLQESGGGLVQAGGSLRLSCEAS-----	1 - 25	25
	Kabat	EVKLQESGGGLVQAGGSLRLSCEASGRTFN	1 - 30	30
	Contact	EVKLQESGGGLVQAGGSLRLSCEASGRTF-	1 - 29	29
	IMGT	EVKLQESGGGLVQAGGSLRLSCEAS-----	1 - 25	25
CDR-H1	Chothia	GRTFNIN---	26 - 32	7
	AbM	GRTFNINSMR	26 - 35	10
	Kabat	-----INSMR	31 - 35	5
	Contact	----NINSMR	30 - 35	6
	IMGT	GRTFNINS--	26 - 33	8
HFR2	Chothia	SMRWYRQAPGKQRDWVASI	33 - 51	19
	AbM	---WYRQAPGKQRDWVA--	36 - 49	14
	Kabat	---WYRQAPGKQRDWVA--	36 - 49	14
	Contact	---WYRQAPGKQRD-----	36 - 46	11
	IMGT	-MRWYRQAPGKQRDWVAS-	34 - 50	17
CDR-H2	Chothia	-----SSGGS---------	52 - 56	5
	AbM	---SISSGGSTY-------	50 - 58	9
	Kabat	---SISSGGSTYYADSVKG	50 - 65	16
	Contact	WVASISSGGSTY-------	47 - 58	12
	IMGT	----ISSGGST--------	51 - 57	7
HFR3	Chothia	TYYADSVKGRFTISRDNAANMVYLQMNDLKPEDTAVYFCTE	57 - 97	41
	AbM	--YADSVKGRFTISRDNAANMVYLQMNDLKPEDTAVYFCTE	59 - 97	39
	Kabat	---------RFTISRDNAANMVYLQMNDLKPEDTAVYFCTE	66 - 97	32
	Contact	--YADSVKGRFTISRDNAANMVYLQMNDLKPEDTAVYFC--	59 - 95	37
	IMGT	-YYADSVKGRFTISRDNAANMVYLQMNDLKPEDTAVYFC--	58 - 95	38
CDR-H3	Chothia	--GVLNVPSLD	98 - 106	9
	AbM	--GVLNVPSLD	98 - 106	9
	Kabat	--GVLNVPSLD	98 - 106	9
	Contact	TEGVLNVPSL-	96 - 105	10
	IMGT	TEGVLNVPSLD	96 - 106	11
HFR4	Chothia	-LGPGTLVVVSA	107 - 117	11
	AbM	-LGPGTLVVVSA	107 - 117	11
	Kabat	-LGPGTLVVVSA	107 - 117	11
	Contact	DLGPGTLVVVSA	106 - 117	12
	IMGT	-LGPGTLVVVSA	107 - 117	11

Accession & Annotations

Accession	ATN23925.1
Source	abYsis-EMBL-IG MF780596 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Reston virus nucleoprotein single domain antibody D
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

EVKLQESGGGLVQAGGSLRLSCEASGRTFNINSMRWYRQAPGKQRDWVASISSGGSTYYA
DSVKGRFTISRDNAANMVYLQMNDLKPEDTAVYFCTEGVLNVPSLDLGPGTLVVVSA

DNA Sequence:

gaggtgaagctgcaggagtcagggggaggcttggtgcaggctggagggtctctgagactc
tcctgtgaagcctctggaaggaccttcaacatcaattccatgcgctggtaccgccaggct
cccgggaagcagcgcgactgggtcgcaagtattagtagtggtggtagcacatactatgca
gactccgtgaagggccggttcaccatctccagggacaacgccgcgaatatggtgtatcta
cagatgaacgatttgaaacctgaagatacggccgtctatttctgtacagagggcgtactt
aacgtcccgtccctcgacctgggcccggggaccctggtcgtcgtctctgcg

Data Source:

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