abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLQESGGGLVQAGGSLRLSCAASGITFS	1 - 30	30
CDR-H1	MYAMV	31 - 35	5
HFR2	WHRQAPGKQRELVA	36 - 49	14
CDR-H2	GISSGGSTRYADSVKD	50 - 65	16
HFR3	RFTISRDNAGSTLTLQMNSLKPEDTAVYYCHA	66 - 97	32
CDR-H3	LLGNIPH	98 - 104	7
HFR4	WGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVKLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVKLQESGGGLVQAGGSLRLSCAASGITFS	1 - 30	30
	Contact	QVKLQESGGGLVQAGGSLRLSCAASGITF-	1 - 29	29
	IMGT	QVKLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GITFSMY---	26 - 32	7
	AbM	GITFSMYAMV	26 - 35	10
	Kabat	-----MYAMV	31 - 35	5
	Contact	----SMYAMV	30 - 35	6
	IMGT	GITFSMYA--	26 - 33	8
HFR2	Chothia	AMVWHRQAPGKQRELVAGI	33 - 51	19
	AbM	---WHRQAPGKQRELVA--	36 - 49	14
	Kabat	---WHRQAPGKQRELVA--	36 - 49	14
	Contact	---WHRQAPGKQRE-----	36 - 46	11
	IMGT	-MVWHRQAPGKQRELVAG-	34 - 50	17
CDR-H2	Chothia	-----SSGGS---------	52 - 56	5
	AbM	---GISSGGSTR-------	50 - 58	9
	Kabat	---GISSGGSTRYADSVKD	50 - 65	16
	Contact	LVAGISSGGSTR-------	47 - 58	12
	IMGT	----ISSGGST--------	51 - 57	7
HFR3	Chothia	TRYADSVKDRFTISRDNAGSTLTLQMNSLKPEDTAVYYCHA	57 - 97	41
	AbM	--YADSVKDRFTISRDNAGSTLTLQMNSLKPEDTAVYYCHA	59 - 97	39
	Kabat	---------RFTISRDNAGSTLTLQMNSLKPEDTAVYYCHA	66 - 97	32
	Contact	--YADSVKDRFTISRDNAGSTLTLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-RYADSVKDRFTISRDNAGSTLTLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--LLGNIPH	98 - 104	7
	AbM	--LLGNIPH	98 - 104	7
	Kabat	--LLGNIPH	98 - 104	7
	Contact	HALLGNIP-	96 - 103	8
	IMGT	HALLGNIPH	96 - 104	9
HFR4	Chothia	-WGQGTQVTVSS	105 - 115	11
	AbM	-WGQGTQVTVSS	105 - 115	11
	Kabat	-WGQGTQVTVSS	105 - 115	11
	Contact	HWGQGTQVTVSS	104 - 115	12
	IMGT	-WGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	ATN23926.1
Source	abYsis-EMBL-IG MF780597 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Reston virus nucleoprotein single domain antibody E
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

QVKLQESGGGLVQAGGSLRLSCAASGITFSMYAMVWHRQAPGKQRELVAGISSGGSTRYA
DSVKDRFTISRDNAGSTLTLQMNSLKPEDTAVYYCHALLGNIPHWGQGTQVTVSS

DNA Sequence:

caggtgaaactgcaggagtctgggggaggcttggtgcaggctggggggtctctgagactc
tcctgtgcagcctctggaattaccttcagtatgtatgcaatggtctggcaccgccaggct
ccagggaagcagcgcgagttggtcgcaggtattagtagtggtggtagtacaaggtatgca
gactccgtaaaggaccgcttcaccatctccagagacaacgccgggagcacgctgactctg
caaatgaacagcctgaaacctgaggacacagccgtctattactgccacgctttattgggt
aacattccccactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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