abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVQLQQSGGGSVTPGGSLRLSCAASGSISD	1 - 30	30
CDR-H1	FAAMA	31 - 35	5
HFR2	WYRQAPGKERDWVG	36 - 49	14
CDR-H2	TIFSAGALLYAEPVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCRL	66 - 97	32
CDR-H3	YAEAIY	98 - 103	6
HFR4	WGQGTQVTVSS	104 - 114	11
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQQSGGGSVTPGGSLRLSCAAS-----	1 - 25	25
	AbM	KVQLQQSGGGSVTPGGSLRLSCAAS-----	1 - 25	25
	Kabat	KVQLQQSGGGSVTPGGSLRLSCAASGSISD	1 - 30	30
	Contact	KVQLQQSGGGSVTPGGSLRLSCAASGSIS-	1 - 29	29
	IMGT	KVQLQQSGGGSVTPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSISDFA---	26 - 32	7
	AbM	GSISDFAAMA	26 - 35	10
	Kabat	-----FAAMA	31 - 35	5
	Contact	----DFAAMA	30 - 35	6
	IMGT	GSISDFAA--	26 - 33	8
HFR2	Chothia	AMAWYRQAPGKERDWVGTI	33 - 51	19
	AbM	---WYRQAPGKERDWVG--	36 - 49	14
	Kabat	---WYRQAPGKERDWVG--	36 - 49	14
	Contact	---WYRQAPGKERD-----	36 - 46	11
	IMGT	-MAWYRQAPGKERDWVGT-	34 - 50	17
CDR-H2	Chothia	-----FSAGA---------	52 - 56	5
	AbM	---TIFSAGALL-------	50 - 58	9
	Kabat	---TIFSAGALLYAEPVKG	50 - 65	16
	Contact	WVGTIFSAGALL-------	47 - 58	12
	IMGT	----IFSAGAL--------	51 - 57	7
HFR3	Chothia	LLYAEPVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCRL	57 - 97	41
	AbM	--YAEPVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCRL	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCRL	66 - 97	32
	Contact	--YAEPVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-LYAEPVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--YAEAIY	98 - 103	6
	AbM	--YAEAIY	98 - 103	6
	Kabat	--YAEAIY	98 - 103	6
	Contact	RLYAEAI-	96 - 102	7
	IMGT	RLYAEAIY	96 - 103	8
HFR4	Chothia	-WGQGTQVTVSS	104 - 114	11
	AbM	-WGQGTQVTVSS	104 - 114	11
	Kabat	-WGQGTQVTVSS	104 - 114	11
	Contact	YWGQGTQVTVSS	103 - 114	12
	IMGT	-WGQGTQVTVSS	104 - 114	11

Accession & Annotations

Accession	ATN23929.1
Source	abYsis-EMBL-IG MF780600 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Zaire virus nucleoprotein single domain antibody C
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVQLQQSGGGSVTPGGSLRLSCAASGSISDFAAMAWYRQAPGKERDWVGTIFSAGALLYA
EPVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCRLYAEAIYWGQGTQVTVSS

DNA Sequence:

aaggtccaactgcagcagtcagggggaggctcggtgacgcctggggggtcgctgagactg
tcctgtgcagcctcgggaagcatctccgatttcgcggccatggcctggtatcgccaggct
ccagggaaggagcgcgattgggtaggaactatttttagtgccggtgcactactctatgca
gagcccgtgaagggccgcttcaccatctccagagacaacgccaagaacacggtgtacctg
caaatgaacagcctaaaacctgaggacacggccgtctattactgtcgtctatatgcagaa
gcgatctattgggggcaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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