abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVKLQESGGGSVQAGGSLRLSCTASGIAVT	1 - 30	30
CDR-H1	NYLVN	31 - 35	5
HFR2	WYRRAPGKPRELVA	36 - 49	14
CDR-H2	SISSGGGRYYTDIAKD	50 - 65	16
HFR3	RFTISRVVANNTVLLHMNSVKPEDTAVYICRL	66 - 97	32
CDR-H3	RGFPVVQGALSEY	98 - 110	13
HFR4	WGQGTQVTVSS	111 - 121	11
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVKLQESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
	AbM	EVKLQESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
	Kabat	EVKLQESGGGSVQAGGSLRLSCTASGIAVT	1 - 30	30
	Contact	EVKLQESGGGSVQAGGSLRLSCTASGIAV-	1 - 29	29
	IMGT	EVKLQESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
CDR-H1	Chothia	GIAVTNY---	26 - 32	7
	AbM	GIAVTNYLVN	26 - 35	10
	Kabat	-----NYLVN	31 - 35	5
	Contact	----TNYLVN	30 - 35	6
	IMGT	GIAVTNYL--	26 - 33	8
HFR2	Chothia	LVNWYRRAPGKPRELVASI	33 - 51	19
	AbM	---WYRRAPGKPRELVA--	36 - 49	14
	Kabat	---WYRRAPGKPRELVA--	36 - 49	14
	Contact	---WYRRAPGKPRE-----	36 - 46	11
	IMGT	-VNWYRRAPGKPRELVAS-	34 - 50	17
CDR-H2	Chothia	-----SSGGG---------	52 - 56	5
	AbM	---SISSGGGRY-------	50 - 58	9
	Kabat	---SISSGGGRYYTDIAKD	50 - 65	16
	Contact	LVASISSGGGRY-------	47 - 58	12
	IMGT	----ISSGGGR--------	51 - 57	7
HFR3	Chothia	RYYTDIAKDRFTISRVVANNTVLLHMNSVKPEDTAVYICRL	57 - 97	41
	AbM	--YTDIAKDRFTISRVVANNTVLLHMNSVKPEDTAVYICRL	59 - 97	39
	Kabat	---------RFTISRVVANNTVLLHMNSVKPEDTAVYICRL	66 - 97	32
	Contact	--YTDIAKDRFTISRVVANNTVLLHMNSVKPEDTAVYIC--	59 - 95	37
	IMGT	-YYTDIAKDRFTISRVVANNTVLLHMNSVKPEDTAVYIC--	58 - 95	38
CDR-H3	Chothia	--RGFPVVQGALSEY	98 - 110	13
	AbM	--RGFPVVQGALSEY	98 - 110	13
	Kabat	--RGFPVVQGALSEY	98 - 110	13
	Contact	RLRGFPVVQGALSE-	96 - 109	14
	IMGT	RLRGFPVVQGALSEY	96 - 110	15
HFR4	Chothia	-WGQGTQVTVSS	111 - 121	11
	AbM	-WGQGTQVTVSS	111 - 121	11
	Kabat	-WGQGTQVTVSS	111 - 121	11
	Contact	YWGQGTQVTVSS	110 - 121	12
	IMGT	-WGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	ATN23930.1
Source	abYsis-EMBL-IG MF780601 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Zaire virus nucleoprotein single domain antibody D
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Sherwood L.J., Hayhurst A. 'Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation' PLoS One 8(4):E61232-E61232(2013). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

EVKLQESGGGSVQAGGSLRLSCTASGIAVTNYLVNWYRRAPGKPRELVASISSGGGRYYT
DIAKDRFTISRVVANNTVLLHMNSVKPEDTAVYICRLRGFPVVQGALSEYWGQGTQVTVS
S

DNA Sequence:

gaggtcaagctgcaggagtcagggggaggctcggtgcaggctggggggtccctgaggctc
tcctgtacagcctctggaatcgccgtcacaaattacctcgtgaactggtaccgccgggct
ccagggaagccgcgcgagttggtcgcaagtattagtagtggtggtggccgatactataca
gacatcgcgaaggaccgattcaccatctccagagtcgtcgccaataatacagtactacta
cacatgaacagcgtaaagcctgaagacacggccgtctatatttgccgcctccgtggcttc
ccggttgtgcaaggggccttatctgagtattggggccaggggacccaggtcaccgtctcc
tca

Data Source:

Alignment settings:

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