abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLQESGGGSVQEGGSLRLSCAASGAFFR	1 - 30	30
CDR-H1	AGPMG	31 - 35	5
HFR2	WYRQAPGRQRDLVA	36 - 49	14
CDR-H2	LIRRDRTTDYADSVKG	50 - 65	16
HFR3	RFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	66 - 97	32
CDR-H3	LGTGF	98 - 102	5
HFR4	FGQGTQVTVSS	103 - 113	11
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLQESGGGSVQEGGSLRLSCAAS-----	1 - 25	25
	AbM	QVKLQESGGGSVQEGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVKLQESGGGSVQEGGSLRLSCAASGAFFR	1 - 30	30
	Contact	QVKLQESGGGSVQEGGSLRLSCAASGAFF-	1 - 29	29
	IMGT	QVKLQESGGGSVQEGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GAFFRAG---	26 - 32	7
	AbM	GAFFRAGPMG	26 - 35	10
	Kabat	-----AGPMG	31 - 35	5
	Contact	----RAGPMG	30 - 35	6
	IMGT	GAFFRAGP--	26 - 33	8
HFR2	Chothia	PMGWYRQAPGRQRDLVALI	33 - 51	19
	AbM	---WYRQAPGRQRDLVA--	36 - 49	14
	Kabat	---WYRQAPGRQRDLVA--	36 - 49	14
	Contact	---WYRQAPGRQRD-----	36 - 46	11
	IMGT	-MGWYRQAPGRQRDLVAL-	34 - 50	17
CDR-H2	Chothia	-----RRDRT---------	52 - 56	5
	AbM	---LIRRDRTTD-------	50 - 58	9
	Kabat	---LIRRDRTTDYADSVKG	50 - 65	16
	Contact	LVALIRRDRTTD-------	47 - 58	12
	IMGT	----IRRDRTT--------	51 - 57	7
HFR3	Chothia	TDYADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	57 - 97	41
	AbM	--YADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	59 - 97	39
	Kabat	---------RFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	66 - 97	32
	Contact	--YADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFC--	59 - 95	37
	IMGT	-DYADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFC--	58 - 95	38
CDR-H3	Chothia	--LGTGF	98 - 102	5
	AbM	--LGTGF	98 - 102	5
	Kabat	--LGTGF	98 - 102	5
	Contact	NPLGTG-	96 - 101	6
	IMGT	NPLGTGF	96 - 102	7
HFR4	Chothia	-FGQGTQVTVSS	103 - 113	11
	AbM	-FGQGTQVTVSS	103 - 113	11
	Kabat	-FGQGTQVTVSS	103 - 113	11
	Contact	FFGQGTQVTVSS	102 - 113	12
	IMGT	-FGQGTQVTVSS	103 - 113	11

Accession & Annotations

Accession	ATN23974.1
Source	abYsis-EMBL-IG MF780604 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-Ebola Zaire virus nucleoprotein single domain antibody G
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Sherwood L.J., Hayhurst A. Submitted (29-AUG-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

QVKLQESGGGSVQEGGSLRLSCAASGAFFRAGPMGWYRQAPGRQRDLVALIRRDRTTDYA
DSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNPLGTGFFGQGTQVTVSS

DNA Sequence:

caggtcaagctgcaggagtctgggggaggctcagtgcaggaaggggggtctctgagactc
tcctgtgcagcctccggagcgttctttagagccggtcccatgggttggtaccgccaggcc
ccggggaggcagcgcgacttggtcgcactaattcgtcgcgataggacgaccgactatgca
gattccgtgaagggccgattcaccatctccagagacgacgccaagaacacggtgtatctg
cagatgaacagcctgaaatctgaggatacagccgtctacttttgtaatccacttgggact
ggcttctttggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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