abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	KVQLQESGGGLVQAGGSLRLSCAASGGTFS	1 - 30	30
CDR-H1	INTLG	31 - 35	5
HFR2	WYRRAPGKEREFVA	36 - 49	14
CDR-H2	RISSGGITRYADSVKG	50 - 65	16
HFR3	RFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	66 - 97	32
CDR-H3	RNWGGGLDVY	98 - 107	10
HFR4	WGQGTQVTVSS	108 - 118	11
Tail	AAAHHHHHHGGGGSTETSQVAPA	118 - 141	23
			141

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	KVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	KVQLQESGGGLVQAGGSLRLSCAASGGTFS	1 - 30	30
	Contact	KVQLQESGGGLVQAGGSLRLSCAASGGTF-	1 - 29	29
	IMGT	KVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GGTFSIN---	26 - 32	7
	AbM	GGTFSINTLG	26 - 35	10
	Kabat	-----INTLG	31 - 35	5
	Contact	----SINTLG	30 - 35	6
	IMGT	GGTFSINT--	26 - 33	8
HFR2	Chothia	TLGWYRRAPGKEREFVARI	33 - 51	19
	AbM	---WYRRAPGKEREFVA--	36 - 49	14
	Kabat	---WYRRAPGKEREFVA--	36 - 49	14
	Contact	---WYRRAPGKERE-----	36 - 46	11
	IMGT	-LGWYRRAPGKEREFVAR-	34 - 50	17
CDR-H2	Chothia	-----SSGGI---------	52 - 56	5
	AbM	---RISSGGITR-------	50 - 58	9
	Kabat	---RISSGGITRYADSVKG	50 - 65	16
	Contact	FVARISSGGITR-------	47 - 58	12
	IMGT	----ISSGGIT--------	51 - 57	7
HFR3	Chothia	TRYADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	57 - 97	41
	AbM	--YADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	59 - 97	39
	Kabat	---------RFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	66 - 97	32
	Contact	--YADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-RYADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--RNWGGGLDVY	98 - 107	10
	AbM	--RNWGGGLDVY	98 - 107	10
	Kabat	--RNWGGGLDVY	98 - 107	10
	Contact	MYRNWGGGLDV-	96 - 106	11
	IMGT	MYRNWGGGLDVY	96 - 107	12
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	YWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	ATN23936.1
Source	abYsis-EMBL-IG MF871579 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-MARV NP single domain antibody B monomer
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

KVQLQESGGGLVQAGGSLRLSCAASGGTFSINTLGWYRRAPGKEREFVARISSGGITRYA
DSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMYRNWGGGLDVYWGQGTQVTVSSAA
AHHHHHHGGGGSTETSQVAPA

DNA Sequence:

aaggtgcagctgcaggagtcagggggaggcttggtgcaggctggggggtctcttagactc
tcctgtgcagcctctggaggcaccttcagtatcaataccctgggctggtaccgccgggcc
ccagggaaggagcgcgagttcgtcgcacgtattagtagtggtggtattacacgctatgca
gactccgtgaagggccgtttcaccatctccagagacaatggcaagaacacagtgtatcta
gacatgaacagcctgaaacctgaggacacggccgtctactattgtatgtaccggaactgg
ggaggtggcctggatgtgtactggggacaggggacccaggtcaccgtctcctcagcggcc
gcacatcaccatcaccatcacggaggcggtggatctaccgaaacttctcaggttgccccg
gcataa

Data Source:

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