abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCTASGFTLA	1 - 30	30
CDR-H1	EYGVG	31 - 35	5
HFR2	WFRQAPGKERELVA	36 - 49	14
CDR-H2	LIAVGGTTHSIDSVKG	50 - 65	16
HFR3	RFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	66 - 97	32
CDR-H3	YSSAYDRNY	98 - 106	9
HFR4	WGQGTQVTVSS	107 - 117	11
Tail	AAAHHHHHHGGGGSTETSQVAPA	117 - 140	23
			140

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCTAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCTAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCTASGFTLA	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCTASGFTL-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCTAS-----	1 - 25	25
CDR-H1	Chothia	GFTLAEY---	26 - 32	7
	AbM	GFTLAEYGVG	26 - 35	10
	Kabat	-----EYGVG	31 - 35	5
	Contact	----AEYGVG	30 - 35	6
	IMGT	GFTLAEYG--	26 - 33	8
HFR2	Chothia	GVGWFRQAPGKERELVALI	33 - 51	19
	AbM	---WFRQAPGKERELVA--	36 - 49	14
	Kabat	---WFRQAPGKERELVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-VGWFRQAPGKERELVAL-	34 - 50	17
CDR-H2	Chothia	-----AVGGT---------	52 - 56	5
	AbM	---LIAVGGTTH-------	50 - 58	9
	Kabat	---LIAVGGTTHSIDSVKG	50 - 65	16
	Contact	LVALIAVGGTTH-------	47 - 58	12
	IMGT	----IAVGGTT--------	51 - 57	7
HFR3	Chothia	THSIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	57 - 97	41
	AbM	--SIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	66 - 97	32
	Contact	--SIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYC--	59 - 95	37
	IMGT	-HSIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--YSSAYDRNY	98 - 106	9
	AbM	--YSSAYDRNY	98 - 106	9
	Kabat	--YSSAYDRNY	98 - 106	9
	Contact	NAYSSAYDRN-	96 - 105	10
	IMGT	NAYSSAYDRNY	96 - 106	11
HFR4	Chothia	-WGQGTQVTVSS	107 - 117	11
	AbM	-WGQGTQVTVSS	107 - 117	11
	Kabat	-WGQGTQVTVSS	107 - 117	11
	Contact	YWGQGTQVTVSS	106 - 117	12
	IMGT	-WGQGTQVTVSS	107 - 117	11

Accession & Annotations

Accession	ATN23938.1
Source	abYsis-EMBL-IG MF871581 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	Anti-EBOV NP single domain antibody E monomer
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCTASGFTLAEYGVGWFRQAPGKERELVALIAVGGTTHSI
DSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNAYSSAYDRNYWGQGTQVTVSSAAA
HHHHHHGGGGSTETSQVAPA

DNA Sequence:

caggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtacagcctctggattcaccttggctgaatatggcgtaggctggttccgccaggcc
ccagggaaggagcgcgagctggtcgcgctaattgccgttggtggtaccacgcactcgata
gactccgtgaagggccgcttcaccatctccagagacaacatgaagaacacagtgtacctg
caaatgaacagcctgaacgttgaggacacggccgtctattactgtaatgcctatagttca
gcctacgaccgaaactactggggccaggggacccaggtcaccgtctcctcagcggccgca
catcaccatcaccatcacggaggcggtggatctaccgaaacttctcaggttgccccggca
taa

Data Source:

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