abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	M	1 - 1	1
HFR1	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	2 - 31	30
CDR-H1	SSAMG	32 - 36	5
HFR2	WYRRAPGKQRELVA	37 - 50	14
CDR-H2	SLTTTGTADYGDFVKG	51 - 66	16
HFR3	RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	67 - 98	32
CDR-H3	DPYGMESLRY	99 - 108	10
HFR4	WGQGTQVTVSS	109 - 119	11
Tail	GGTETSQVAPA	119 - 130	11
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQVGGSLRLSCKAS-----	2 - 26	25
	AbM	KVQLQESGGGLVQVGGSLRLSCKAS-----	2 - 26	25
	Kabat	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	2 - 31	30
	Contact	KVQLQESGGGLVQVGGSLRLSCKASGFTF-	2 - 30	29
	IMGT	KVQLQESGGGLVQVGGSLRLSCKAS-----	2 - 26	25
CDR-H1	Chothia	GFTFRSS---	27 - 33	7
	AbM	GFTFRSSAMG	27 - 36	10
	Kabat	-----SSAMG	32 - 36	5
	Contact	----RSSAMG	31 - 36	6
	IMGT	GFTFRSSA--	27 - 34	8
HFR2	Chothia	AMGWYRRAPGKQRELVASL	34 - 52	19
	AbM	---WYRRAPGKQRELVA--	37 - 50	14
	Kabat	---WYRRAPGKQRELVA--	37 - 50	14
	Contact	---WYRRAPGKQRE-----	37 - 47	11
	IMGT	-MGWYRRAPGKQRELVAS-	35 - 51	17
CDR-H2	Chothia	-----TTTGT---------	53 - 57	5
	AbM	---SLTTTGTAD-------	51 - 59	9
	Kabat	---SLTTTGTADYGDFVKG	51 - 66	16
	Contact	LVASLTTTGTAD-------	48 - 59	12
	IMGT	----LTTTGTA--------	52 - 58	7
HFR3	Chothia	ADYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	58 - 98	41
	AbM	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	60 - 98	39
	Kabat	---------RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	67 - 98	32
	Contact	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-DYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DPYGMESLRY	99 - 108	10
	AbM	--DPYGMESLRY	99 - 108	10
	Kabat	--DPYGMESLRY	99 - 108	10
	Contact	HEDPYGMESLR-	97 - 107	11
	IMGT	HEDPYGMESLRY	97 - 108	12
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	ATN23947.1
Source	abYsis-EMBL-IG MF871590 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-MARV NP single domain antibody C
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: ATN23942.1
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

MKVQLQESGGGLVQVGGSLRLSCKASGFTFRSSAMGWYRRAPGKQRELVASLTTTGTADY
GDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHEDPYGMESLRYWGQGTQVTVSSG
GTETSQVAPA

DNA Sequence:

atgaaggtgcagctgcaggagtctgggggaggcttagtgcaggttggggggtctctgaga
ctctcctgtaaagcgtctggatttactttccgatcgtccgccatgggttggtatcgccgg
gctccagggaagcagcgcgagttggtcgcctctctcaccacaactgggaccgcggactat
ggagactttgtgaagggccgattcaccatctcgagagacaacgccgagaacacggtggat
ctgcatatgaacagcctgaaacctgaggacacggccgtctactactgtcatgaagatcct
tacggaatggaatcccttcgctactggggccaggggacccaggtcaccgtctcctcaggc
gggaccgaaacatctcaggtggcccccgcttga

Data Source:

Alignment settings:

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