abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MG	1 - 2	2
HFR1	QVKLQESGGGSVQEGGSLRLSCAASGAFFR	3 - 32	30
CDR-H1	AGPMG	33 - 37	5
HFR2	WYRQAPGRQRDLVA	38 - 51	14
CDR-H2	LIRRDRTTDYADSVKG	52 - 67	16
HFR3	RFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	68 - 99	32
CDR-H3	LGTGF	100 - 104	5
HFR4	FGQGTQVTVSS	105 - 115	11
Tail	GGTETSQVAPA	115 - 126	11
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLQESGGGSVQEGGSLRLSCAAS-----	3 - 27	25
	AbM	QVKLQESGGGSVQEGGSLRLSCAAS-----	3 - 27	25
	Kabat	QVKLQESGGGSVQEGGSLRLSCAASGAFFR	3 - 32	30
	Contact	QVKLQESGGGSVQEGGSLRLSCAASGAFF-	3 - 31	29
	IMGT	QVKLQESGGGSVQEGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GAFFRAG---	28 - 34	7
	AbM	GAFFRAGPMG	28 - 37	10
	Kabat	-----AGPMG	33 - 37	5
	Contact	----RAGPMG	32 - 37	6
	IMGT	GAFFRAGP--	28 - 35	8
HFR2	Chothia	PMGWYRQAPGRQRDLVALI	35 - 53	19
	AbM	---WYRQAPGRQRDLVA--	38 - 51	14
	Kabat	---WYRQAPGRQRDLVA--	38 - 51	14
	Contact	---WYRQAPGRQRD-----	38 - 48	11
	IMGT	-MGWYRQAPGRQRDLVAL-	36 - 52	17
CDR-H2	Chothia	-----RRDRT---------	54 - 58	5
	AbM	---LIRRDRTTD-------	52 - 60	9
	Kabat	---LIRRDRTTDYADSVKG	52 - 67	16
	Contact	LVALIRRDRTTD-------	49 - 60	12
	IMGT	----IRRDRTT--------	53 - 59	7
HFR3	Chothia	TDYADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	59 - 99	41
	AbM	--YADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	61 - 99	39
	Kabat	---------RFTISRDDAKNTVYLQMNSLKSEDTAVYFCNP	68 - 99	32
	Contact	--YADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFC--	61 - 97	37
	IMGT	-DYADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFC--	60 - 97	38
CDR-H3	Chothia	--LGTGF	100 - 104	5
	AbM	--LGTGF	100 - 104	5
	Kabat	--LGTGF	100 - 104	5
	Contact	NPLGTG-	98 - 103	6
	IMGT	NPLGTGF	98 - 104	7
HFR4	Chothia	-FGQGTQVTVSS	105 - 115	11
	AbM	-FGQGTQVTVSS	105 - 115	11
	Kabat	-FGQGTQVTVSS	105 - 115	11
	Contact	FFGQGTQVTVSS	104 - 115	12
	IMGT	-FGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	ATN23949.1
Source	abYsis-EMBL-IG MF871592 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-EBOV NP single domain antibody G
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: ATN23944.1
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

MGQVKLQESGGGSVQEGGSLRLSCAASGAFFRAGPMGWYRQAPGRQRDLVALIRRDRTTD
YADSVKGRFTISRDDAKNTVYLQMNSLKSEDTAVYFCNPLGTGFFGQGTQVTVSSGGTET
SQVAPA

DNA Sequence:

atgggacaggtcaagctgcaggagtctgggggaggctcagtgcaggaaggggggtctctg
agactctcctgtgcagcctccggagcgttctttagagccggtcccatgggttggtaccgc
caggccccggggaggcagcgcgacttggtcgcactaattcgtcgcgataggacgaccgac
tatgcagattccgtgaagggccgattcaccatctccagagacgacgccaagaacacggtg
tatctgcagatgaacagcctgaaatctgaggatacagccgtctacttttgtaatccactt
gggactggcttctttggccaggggacccaggtcaccgtctcctcaggaggaacagagaca
tcccaggtcgcacccgcatga

Data Source:

Alignment settings:

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