abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	KVQLQESGGGLVQAGGSLRLSCAASGGTFS	3 - 32	30
CDR-H1	INTLG	33 - 37	5
HFR2	WYRRAPGKEREFVA	38 - 51	14
CDR-H2	RISSGGITRYADSVKG	52 - 67	16
HFR3	RFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	68 - 99	32
CDR-H3	RNWGGGLDVY	100 - 109	10
HFR4	WGQGTQVTVSS	110 - 120	11
Tail	AAAHHHHHHGGGGSTETSQVAPA	120 - 143	23
			143

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	KVQLQESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	KVQLQESGGGLVQAGGSLRLSCAASGGTFS	3 - 32	30
	Contact	KVQLQESGGGLVQAGGSLRLSCAASGGTF-	3 - 31	29
	IMGT	KVQLQESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GGTFSIN---	28 - 34	7
	AbM	GGTFSINTLG	28 - 37	10
	Kabat	-----INTLG	33 - 37	5
	Contact	----SINTLG	32 - 37	6
	IMGT	GGTFSINT--	28 - 35	8
HFR2	Chothia	TLGWYRRAPGKEREFVARI	35 - 53	19
	AbM	---WYRRAPGKEREFVA--	38 - 51	14
	Kabat	---WYRRAPGKEREFVA--	38 - 51	14
	Contact	---WYRRAPGKERE-----	38 - 48	11
	IMGT	-LGWYRRAPGKEREFVAR-	36 - 52	17
CDR-H2	Chothia	-----SSGGI---------	54 - 58	5
	AbM	---RISSGGITR-------	52 - 60	9
	Kabat	---RISSGGITRYADSVKG	52 - 67	16
	Contact	FVARISSGGITR-------	49 - 60	12
	IMGT	----ISSGGIT--------	53 - 59	7
HFR3	Chothia	TRYADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	59 - 99	41
	AbM	--YADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	61 - 99	39
	Kabat	---------RFTISRDNGKNTVYLDMNSLKPEDTAVYYCMY	68 - 99	32
	Contact	--YADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYC--	61 - 97	37
	IMGT	-RYADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--RNWGGGLDVY	100 - 109	10
	AbM	--RNWGGGLDVY	100 - 109	10
	Kabat	--RNWGGGLDVY	100 - 109	10
	Contact	MYRNWGGGLDV-	98 - 108	11
	IMGT	MYRNWGGGLDVY	98 - 109	12
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	ATN23958.1
Source	abYsis-EMBL-IG MF871601 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-MARV NP single domain antibody B monomer
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

MAKVQLQESGGGLVQAGGSLRLSCAASGGTFSINTLGWYRRAPGKEREFVARISSGGITR
YADSVKGRFTISRDNGKNTVYLDMNSLKPEDTAVYYCMYRNWGGGLDVYWGQGTQVTVSS
AAAHHHHHHGGGGSTETSQVAPA

DNA Sequence:

atggcgaaggtgcagctgcaggagtcagggggaggcttggtgcaggctggggggtctctt
agactctcctgtgcagcctctggaggcaccttcagtatcaataccctgggctggtaccgc
cgggccccagggaaggagcgcgagttcgtcgcacgtattagtagtggtggtattacacgc
tatgcagactccgtgaagggccgtttcaccatctccagagacaatggcaagaacacagtg
tatctagacatgaacagcctgaaacctgaggacacggccgtctactattgtatgtaccgg
aactggggaggtggcctggatgtgtactggggacaggggacccaggtcaccgtctcctca
gcggccgcacatcaccatcaccatcacggaggcggtggatctaccgaaacttctcaggtt
gccccggcataa

Data Source:

Alignment settings:

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