abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	3 - 32	30
CDR-H1	SSAMG	33 - 37	5
HFR2	WYRRAPGKQRELVA	38 - 51	14
CDR-H2	SLTTTGTADYGDFVKG	52 - 67	16
HFR3	RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	68 - 99	32
CDR-H3	DPYGMESLRY	100 - 109	10
HFR4	WGQGTQVTVSS	110 - 120	11
Tail	AAAHHHHHHGGGGSTETSQVAPA	120 - 143	23
			143

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	KVQLQESGGGLVQVGGSLRLSCKAS-----	3 - 27	25
	AbM	KVQLQESGGGLVQVGGSLRLSCKAS-----	3 - 27	25
	Kabat	KVQLQESGGGLVQVGGSLRLSCKASGFTFR	3 - 32	30
	Contact	KVQLQESGGGLVQVGGSLRLSCKASGFTF-	3 - 31	29
	IMGT	KVQLQESGGGLVQVGGSLRLSCKAS-----	3 - 27	25
CDR-H1	Chothia	GFTFRSS---	28 - 34	7
	AbM	GFTFRSSAMG	28 - 37	10
	Kabat	-----SSAMG	33 - 37	5
	Contact	----RSSAMG	32 - 37	6
	IMGT	GFTFRSSA--	28 - 35	8
HFR2	Chothia	AMGWYRRAPGKQRELVASL	35 - 53	19
	AbM	---WYRRAPGKQRELVA--	38 - 51	14
	Kabat	---WYRRAPGKQRELVA--	38 - 51	14
	Contact	---WYRRAPGKQRE-----	38 - 48	11
	IMGT	-MGWYRRAPGKQRELVAS-	36 - 52	17
CDR-H2	Chothia	-----TTTGT---------	54 - 58	5
	AbM	---SLTTTGTAD-------	52 - 60	9
	Kabat	---SLTTTGTADYGDFVKG	52 - 67	16
	Contact	LVASLTTTGTAD-------	49 - 60	12
	IMGT	----LTTTGTA--------	53 - 59	7
HFR3	Chothia	ADYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	59 - 99	41
	AbM	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	61 - 99	39
	Kabat	---------RFTISRDNAENTVDLHMNSLKPEDTAVYYCHE	68 - 99	32
	Contact	--YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	61 - 97	37
	IMGT	-DYGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--DPYGMESLRY	100 - 109	10
	AbM	--DPYGMESLRY	100 - 109	10
	Kabat	--DPYGMESLRY	100 - 109	10
	Contact	HEDPYGMESLR-	98 - 108	11
	IMGT	HEDPYGMESLRY	98 - 109	12
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	ATN23960.1
Source	abYsis-EMBL-IG MF871603 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-MARV NP single domain antibody C monomer
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

MAKVQLQESGGGLVQVGGSLRLSCKASGFTFRSSAMGWYRRAPGKQRELVASLTTTGTAD
YGDFVKGRFTISRDNAENTVDLHMNSLKPEDTAVYYCHEDPYGMESLRYWGQGTQVTVSS
AAAHHHHHHGGGGSTETSQVAPA

DNA Sequence:

atggcgaaggtgcagctgcaggagtctgggggaggcttagtgcaggttggggggtctctg
agactctcctgtaaagcgtctggatttactttccgatcgtccgctatgggttggtatcgc
cgggctccagggaagcagcgcgagttggtcgcctctctcaccacaactgggaccgcggac
tatggagactttgtgaagggccgattcaccatctcgagagacaacgccgagaacacggtg
gatctgcatatgaacagcctgaaacctgaggacacggccgtctactactgtcatgaagat
ccttacggaatggaatcccttcgctactggggccaggggacccaggtcaccgtctcctca
gcggccgcacatcaccatcaccatcacggaggcggtggatctaccgaaacttctcaggtt
gccccggcataa

Data Source:

Alignment settings:

Search settings: