abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVQLQESGGGLVQPGGSLRLSCTASGFTLA	3 - 32	30
CDR-H1	EYGVG	33 - 37	5
HFR2	WFRQAPGKERELVA	38 - 51	14
CDR-H2	LIAVGGTTHSIDSVKG	52 - 67	16
HFR3	RFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	68 - 99	32
CDR-H3	YSSAYDRNY	100 - 108	9
HFR4	WGQGTQVTVSS	109 - 119	11
Tail	AAAHHHHHHGGGGSTETSQVAPA	119 - 142	23
			142

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCTAS-----	3 - 27	25
	AbM	QVQLQESGGGLVQPGGSLRLSCTAS-----	3 - 27	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCTASGFTLA	3 - 32	30
	Contact	QVQLQESGGGLVQPGGSLRLSCTASGFTL-	3 - 31	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCTAS-----	3 - 27	25
CDR-H1	Chothia	GFTLAEY---	28 - 34	7
	AbM	GFTLAEYGVG	28 - 37	10
	Kabat	-----EYGVG	33 - 37	5
	Contact	----AEYGVG	32 - 37	6
	IMGT	GFTLAEYG--	28 - 35	8
HFR2	Chothia	GVGWFRQAPGKERELVALI	35 - 53	19
	AbM	---WFRQAPGKERELVA--	38 - 51	14
	Kabat	---WFRQAPGKERELVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-VGWFRQAPGKERELVAL-	36 - 52	17
CDR-H2	Chothia	-----AVGGT---------	54 - 58	5
	AbM	---LIAVGGTTH-------	52 - 60	9
	Kabat	---LIAVGGTTHSIDSVKG	52 - 67	16
	Contact	LVALIAVGGTTH-------	49 - 60	12
	IMGT	----IAVGGTT--------	53 - 59	7
HFR3	Chothia	THSIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	59 - 99	41
	AbM	--SIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	61 - 99	39
	Kabat	---------RFTISRDNMKNTVYLQMNSLNVEDTAVYYCNA	68 - 99	32
	Contact	--SIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYC--	61 - 97	37
	IMGT	-HSIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--YSSAYDRNY	100 - 108	9
	AbM	--YSSAYDRNY	100 - 108	9
	Kabat	--YSSAYDRNY	100 - 108	9
	Contact	NAYSSAYDRN-	98 - 107	10
	IMGT	NAYSSAYDRNY	98 - 108	11
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	ATN23962.1
Source	abYsis-EMBL-IG MF871605 Submitted 28-OCT-2017 Updated 28-OCT-2017
Name	anti-EBOV NP single domain antibody E monomer
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Darling T.L., Sherwood L.J., Hayhurst A. 'Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging' Front Immunol 8:1197-1197(2017). Darling T.L., Sherwood L.J., Hayhurst A. Submitted (05-SEP-2017) to the INSDC. Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA

Tools

Sequences

Amino Acid Sequence:

MAQVQLQESGGGLVQPGGSLRLSCTASGFTLAEYGVGWFRQAPGKERELVALIAVGGTTH
SIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNAYSSAYDRNYWGQGTQVTVSSA
AAHHHHHHGGGGSTETSQVAPA

DNA Sequence:

atggcgcaggtgcagctgcaggagtctgggggaggcttggtgcagcctggggggtctctg
agactctcctgtacagcctctggattcaccttggctgaatatggcgtaggctggttccgc
caggccccagggaaggagcgcgagctggtcgcgctaattgccgttggtggtaccacgcac
tcgatagactccgtgaagggccgcttcaccatctccagagacaacatgaagaacacagtg
tacctgcaaatgaacagcctgaacgttgaggacacggccgtctattactgtaatgcctat
agttcagcctacgaccgaaactactggggccaggggacccaggtcaccgtctcctcagcg
gccgcacatcaccatcaccatcacggaggcggtggatctaccgaaacttctcaggttgcc
ccggcataa

Data Source:

Alignment settings:

Search settings: