abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGSVQTGGSLRLSCAASGFSFS	1 - 30	30
CDR-H1	SNVMG	31 - 35	5
HFR2	WFRQAPGKEREGVA	36 - 49	14
CDR-H2	AISVDSGSTWYADSVKG	50 - 66	17
HFR3	RFTISLDSANNTLYLQMNSLKPEDTAMYYCAT	67 - 98	32
CDR-H3	RRGVILTLSPETYDY	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGSVQTGGSLRLSCAASGFSFS	1 - 30	30
	Contact	EVQLVESGGGSVQTGGSLRLSCAASGFSF-	1 - 29	29
	IMGT	EVQLVESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFSFSSN---	26 - 32	7
	AbM	GFSFSSNVMG	26 - 35	10
	Kabat	-----SNVMG	31 - 35	5
	Contact	----SSNVMG	30 - 35	6
	IMGT	GFSFSSNV--	26 - 33	8
HFR2	Chothia	VMGWFRQAPGKEREGVAAI	33 - 51	19
	AbM	---WFRQAPGKEREGVA--	36 - 49	14
	Kabat	---WFRQAPGKEREGVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREGVAA-	34 - 50	17
CDR-H2	Chothia	-----SVDSGS---------	52 - 57	6
	AbM	---AISVDSGSTW-------	50 - 59	10
	Kabat	---AISVDSGSTWYADSVKG	50 - 66	17
	Contact	GVAAISVDSGSTW-------	47 - 59	13
	IMGT	----ISVDSGST--------	51 - 58	8
HFR3	Chothia	TWYADSVKGRFTISLDSANNTLYLQMNSLKPEDTAMYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISLDSANNTLYLQMNSLKPEDTAMYYCAT	60 - 98	39
	Kabat	---------RFTISLDSANNTLYLQMNSLKPEDTAMYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISLDSANNTLYLQMNSLKPEDTAMYYC--	60 - 96	37
	IMGT	-WYADSVKGRFTISLDSANNTLYLQMNSLKPEDTAMYYC--	59 - 96	38
CDR-H3	Chothia	--RRGVILTLSPETYDY	99 - 113	15
	AbM	--RRGVILTLSPETYDY	99 - 113	15
	Kabat	--RRGVILTLSPETYDY	99 - 113	15
	Contact	ATRRGVILTLSPETYD-	97 - 112	16
	IMGT	ATRRGVILTLSPETYDY	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	AXU39122.1
Source	abYsis-EMBL-IG MH550666 Submitted 13-SEP-2018 Updated 13-SEP-2018
Name	anti-PEDV membrane protein immunoglobulin heavy chain variable region
Clone	sdAb-MC30
Organism	Camelus bactrianus
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Yang S., Li L., Yin S., Shang Y., Khan M.U., He X., Yuan L., Gao X., Liu X., Cai J. 'Single-domain antibodies as promising experimental tools in imaging and isolation of porcine epidemic diarrhea virus' Appl Microbiol Biotechnol 102(20):8931-8942(2018). Yang S., Yin S., Shang Y., Liu X., Cai J. Submitted (29-JUN-2018) to the INSDC. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, 1 Xujiaping, Yanchangpu, Chengguan District, Lanzhou, Gansu 730046, China

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGSVQTGGSLRLSCAASGFSFSSNVMGWFRQAPGKEREGVAAISVDSGSTWY
ADSVKGRFTISLDSANNTLYLQMNSLKPEDTAMYYCATRRGVILTLSPETYDYWGQGTQV
TVSS

DNA Sequence:

gaggtgcagctggtggagtctgggggaggctcggtgcagactggagggtctctgagactc
tcctgcgcagcctctgggttctcctttagtagcaacgtcatgggctggttccgccaggct
ccagggaaggaacgcgagggggtcgcagctatttcggttgatagtggtagcacatggtat
gccgactccgtgaagggccgattcaccatctccctggacagcgccaacaacacgctgtat
ctgcaaatgaacagcctgaaacctgaggacactgccatgtactactgtgcgactagacgt
ggagttattcttacactgagcccagagacctatgactactggggccaggggacccaggtc
accgtctcctca

Data Source:

Alignment settings:

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