abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVQLVESGGGLVRPGGSLRLSCVDSERTS	3 - 31	29
CDR-H1	YPMG	32 - 35	4
HFR2	WFRRAPGKEREFVA	36 - 49	14
CDR-H2	SITWSGIDPTYADSVAD	50 - 66	17
HFR3	RFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	67 - 98	32
CDR-H3	RAPVGQSSSPYDYDY	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	HHHHHHEPEA	124 - 134	10
			134

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVRPGGSLRLSCVDS----	3 - 27	25
	AbM	QVQLVESGGGLVRPGGSLRLSCVDS----	3 - 27	25
	Kabat	QVQLVESGGGLVRPGGSLRLSCVDSERTS	3 - 31	29
	Contact	QVQLVESGGGLVRPGGSLRLSCVDSERTS	3 - 31	29
	IMGT	QVQLVESGGGLVRPGGSLRLSCVDS----	3 - 27	25
CDR-H1	Chothia	ERTSY---	28 - 32	5
	AbM	ERTSYPMG	28 - 35	8
	Kabat	----YPMG	32 - 35	4
	Contact	----YPMG	32 - 35	4
	IMGT	ERTSYP--	28 - 33	6
HFR2	Chothia	PMGWFRRAPGKEREFVASI	33 - 51	19
	AbM	---WFRRAPGKEREFVA--	36 - 49	14
	Kabat	---WFRRAPGKEREFVA--	36 - 49	14
	Contact	---WFRRAPGKERE-----	36 - 46	11
	IMGT	-MGWFRRAPGKEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----TWSGID---------	52 - 57	6
	AbM	---SITWSGIDPT-------	50 - 59	10
	Kabat	---SITWSGIDPTYADSVAD	50 - 66	17
	Contact	FVASITWSGIDPT-------	47 - 59	13
	IMGT	----ITWSGIDP--------	51 - 58	8
HFR3	Chothia	PTYADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	58 - 98	41
	AbM	--YADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	67 - 98	32
	Contact	--YADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYC--	60 - 96	37
	IMGT	-TYADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--RAPVGQSSSPYDYDY	99 - 113	15
	AbM	--RAPVGQSSSPYDYDY	99 - 113	15
	Kabat	--RAPVGQSSSPYDYDY	99 - 113	15
	Contact	AARAPVGQSSSPYDYD-	97 - 112	16
	IMGT	AARAPVGQSSSPYDYDY	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	6b73_D
Source	PDB 6b73 Submitted 03-OCT-2017 Updated 24-JAN-2018
Name	CRYSTAL STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE KAPPA- OPIOID RECEPTOR
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 6b73_C
References	CHE T., MAJUMDAR S., ZAIDI A., ONDACHI P., MCCORVY D., WANG S., MOSIER D., UPRETY R., VARDY E., KRUMM E., HAN W., LEE Y., PARDON E., STEYAERT J., HUANG P., STRACHAN T., TRIBO R., PASTERNAK W., CARROLL I., STEVENS C., CHEREZOV V., KATRITCH V., WACKER D., ROTH L. 'STRUCTURE OF THE NANOBODY-STABILIZED ACTIVE STATE OF THE KAPPA OPIOID RECEPTOR.' CELL V. 172 55 2018 ISSN 1097-4172

Tools

Sequences

Amino Acid Sequence:

MAQVQLVESGGGLVRPGGSLRLSCVDSERTSYPMGWFRRAPGKEREFVASITWSGIDPTY
ADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAARAPVGQSSSPYDYDYWGQGTQV
TVSSHHHHHHEPEA