abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	VQLVESGGGLVQAGDSLRLSCAASGGTFS	1 - 29	29
CDR-H1	TFNMG	30 - 34	5
HFR2	WFRQDLGKEREFVA	35 - 48	14
CDR-H2	AIRWTGGRAYYGDSVKG	49 - 65	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAR	66 - 97	32
CDR-H3	QGTNGGGYSEATSYNY	98 - 113	16
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	H	124 - 125	1
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VQLVESGGGLVQAGDSLRLSCAAS-----	1 - 24	24
	AbM	VQLVESGGGLVQAGDSLRLSCAAS-----	1 - 24	24
	Kabat	VQLVESGGGLVQAGDSLRLSCAASGGTFS	1 - 29	29
	Contact	VQLVESGGGLVQAGDSLRLSCAASGGTF-	1 - 28	28
	IMGT	VQLVESGGGLVQAGDSLRLSCAAS-----	1 - 24	24
CDR-H1	Chothia	GGTFSTF---	25 - 31	7
	AbM	GGTFSTFNMG	25 - 34	10
	Kabat	-----TFNMG	30 - 34	5
	Contact	----STFNMG	29 - 34	6
	IMGT	GGTFSTFN--	25 - 32	8
HFR2	Chothia	NMGWFRQDLGKEREFVAAI	32 - 50	19
	AbM	---WFRQDLGKEREFVA--	35 - 48	14
	Kabat	---WFRQDLGKEREFVA--	35 - 48	14
	Contact	---WFRQDLGKERE-----	35 - 45	11
	IMGT	-MGWFRQDLGKEREFVAA-	33 - 49	17
CDR-H2	Chothia	-----RWTGGR---------	51 - 56	6
	AbM	---AIRWTGGRAY-------	49 - 58	10
	Kabat	---AIRWTGGRAYYGDSVKG	49 - 65	17
	Contact	FVAAIRWTGGRAY-------	46 - 58	13
	IMGT	----IRWTGGRA--------	50 - 57	8
HFR3	Chothia	AYYGDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAR	57 - 97	41
	AbM	--YGDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAR	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAR	66 - 97	32
	Contact	--YGDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-YYGDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--QGTNGGGYSEATSYNY	98 - 113	16
	AbM	--QGTNGGGYSEATSYNY	98 - 113	16
	Kabat	--QGTNGGGYSEATSYNY	98 - 113	16
	Contact	ARQGTNGGGYSEATSYN-	96 - 112	17
	IMGT	ARQGTNGGGYSEATSYNY	96 - 113	18
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	6c9w_B
Source	PDB 6c9w Submitted 29-JAN-2018 Updated 20-FEB-2019
Name	CRYSTAL STRUCTURE OF A LIGAND BOUND LACY/NANOBODY COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	KUMAR H., FINER-MOORE S., JIANG X., SMIRNOVA I., KASHO V., PARDON E., STEYAERT J., KABACK R., STROUD M. 'CRYSTAL STRUCTURE OF A LIGAND-BOUND LACY-NANOBODY COMPLEX.' PROC. NATL. ACAD. SCI. V. 115 8769 2018 U.S.A. ESSN 1091-6490

Tools

Sequences

Amino Acid Sequence:

VQLVESGGGLVQAGDSLRLSCAASGGTFSTFNMGWFRQDLGKEREFVAAIRWTGGRAYYG
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCARQGTNGGGYSEATSYNYWGQGTQV
TVSSH