abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLEESGGGLVQAGGSLRLSCAASGSTFS	1 - 30	30
CDR-H1	IYTMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	DISWNGGSTYYADSVKG	50 - 66	17
HFR3	RFTIYRDNYKNTVYLQMNSLKPEDTAVYYCNA	67 - 98	32
CDR-H3	DDLMIDRDY	99 - 107	9
HFR4	WGQGTQVTVSS	108 - 118	11
Tail	GSEQKLISEEDLNHHHHHH	118 - 137	19
			137

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLEESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVKLEESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVKLEESGGGLVQAGGSLRLSCAASGSTFS	1 - 30	30
	Contact	QVKLEESGGGLVQAGGSLRLSCAASGSTF-	1 - 29	29
	IMGT	QVKLEESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSTFSIY---	26 - 32	7
	AbM	GSTFSIYTMG	26 - 35	10
	Kabat	-----IYTMG	31 - 35	5
	Contact	----SIYTMG	30 - 35	6
	IMGT	GSTFSIYT--	26 - 33	8
HFR2	Chothia	TMGWFRQAPGKEREFVADI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAD-	34 - 50	17
CDR-H2	Chothia	-----SWNGGS---------	52 - 57	6
	AbM	---DISWNGGSTY-------	50 - 59	10
	Kabat	---DISWNGGSTYYADSVKG	50 - 66	17
	Contact	FVADISWNGGSTY-------	47 - 59	13
	IMGT	----ISWNGGST--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTIYRDNYKNTVYLQMNSLKPEDTAVYYCNA	58 - 98	41
	AbM	--YADSVKGRFTIYRDNYKNTVYLQMNSLKPEDTAVYYCNA	60 - 98	39
	Kabat	---------RFTIYRDNYKNTVYLQMNSLKPEDTAVYYCNA	67 - 98	32
	Contact	--YADSVKGRFTIYRDNYKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTIYRDNYKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DDLMIDRDY	99 - 107	9
	AbM	--DDLMIDRDY	99 - 107	9
	Kabat	--DDLMIDRDY	99 - 107	9
	Contact	NADDLMIDRD-	97 - 106	10
	IMGT	NADDLMIDRDY	97 - 107	11
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	YWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	6dbe_A
Source	PDB 6dbe Submitted 03-MAY-2018 Updated 12-SEP-2018
Name	CRYSTAL STRUCTURE OF VHH R330
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 6dbe_B
References	KING T., HUH I., SHENAI A., BROOKS M., BROOKS L. 'STRUCTURAL BASIS OF VHH-MEDIATED NEUTRALIZATION OF THE FOOD-BORNE PATHOGENLISTERIA MONOCYTOGENES.' J. BIOL. CHEM. V. 293 13626 2018 ESSN 1083-351X

Tools

Sequences

Amino Acid Sequence:

QVKLEESGGGLVQAGGSLRLSCAASGSTFSIYTMGWFRQAPGKEREFVADISWNGGSTYY
ADSVKGRFTIYRDNYKNTVYLQMNSLKPEDTAVYYCNADDLMIDRDYWGQGTQVTVSSGS
EQKLISEEDLNHHHHHH