abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLEESGGGSVQAGGSLRLSCAASGHTYS	1 - 30	30
CDR-H1	TYCMG	31 - 35	5
HFR2	WFRQVPGKEREGVA	36 - 49	14
CDR-H2	RINVGGSSTWYADSVRD	50 - 66	17
HFR3	RFTISQDNAKNTVYLQMNSLKLEDTAIYYCTL	67 - 98	32
CDR-H3	HRFCNTWSLGTLNV	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
Tail	GSEQKLISEEDLNHHHHHH	123 - 142	19
			142

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVKLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVKLEESGGGSVQAGGSLRLSCAASGHTYS	1 - 30	30
	Contact	QVKLEESGGGSVQAGGSLRLSCAASGHTY-	1 - 29	29
	IMGT	QVKLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GHTYSTY---	26 - 32	7
	AbM	GHTYSTYCMG	26 - 35	10
	Kabat	-----TYCMG	31 - 35	5
	Contact	----STYCMG	30 - 35	6
	IMGT	GHTYSTYC--	26 - 33	8
HFR2	Chothia	CMGWFRQVPGKEREGVARI	33 - 51	19
	AbM	---WFRQVPGKEREGVA--	36 - 49	14
	Kabat	---WFRQVPGKEREGVA--	36 - 49	14
	Contact	---WFRQVPGKERE-----	36 - 46	11
	IMGT	-MGWFRQVPGKEREGVAR-	34 - 50	17
CDR-H2	Chothia	-----NVGGSS---------	52 - 57	6
	AbM	---RINVGGSSTW-------	50 - 59	10
	Kabat	---RINVGGSSTWYADSVRD	50 - 66	17
	Contact	GVARINVGGSSTW-------	47 - 59	13
	IMGT	----INVGGSST--------	51 - 58	8
HFR3	Chothia	TWYADSVRDRFTISQDNAKNTVYLQMNSLKLEDTAIYYCTL	58 - 98	41
	AbM	--YADSVRDRFTISQDNAKNTVYLQMNSLKLEDTAIYYCTL	60 - 98	39
	Kabat	---------RFTISQDNAKNTVYLQMNSLKLEDTAIYYCTL	67 - 98	32
	Contact	--YADSVRDRFTISQDNAKNTVYLQMNSLKLEDTAIYYC--	60 - 96	37
	IMGT	-WYADSVRDRFTISQDNAKNTVYLQMNSLKLEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--HRFCNTWSLGTLNV	99 - 112	14
	AbM	--HRFCNTWSLGTLNV	99 - 112	14
	Kabat	--HRFCNTWSLGTLNV	99 - 112	14
	Contact	TLHRFCNTWSLGTLN-	97 - 111	15
	IMGT	TLHRFCNTWSLGTLNV	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	VWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	6dbg_D
Source	PDB 6dbg Submitted 03-MAY-2018 Updated 12-SEP-2018
Name	CRYSTAL STRUCTURE OF VHH R303 IN COMPLEX WITH INLB-LRR-IR
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 6dba_A 6dba_B 6dbf_B 6dbg_C
References	KING T., HUH I., SHENAI A., BROOKS M., BROOKS L. 'STRUCTURAL BASIS OF VHH-MEDIATED NEUTRALIZATION OF THE FOOD-BORNE PATHOGENLISTERIA MONOCYTOGENES.' J. BIOL. CHEM. V. 293 13626 2018 ESSN 1083-351X

Tools

Sequences

Amino Acid Sequence:

QVKLEESGGGSVQAGGSLRLSCAASGHTYSTYCMGWFRQVPGKEREGVARINVGGSSTWY
ADSVRDRFTISQDNAKNTVYLQMNSLKLEDTAIYYCTLHRFCNTWSLGTLNVWGQGTQVT
VSSGSEQKLISEEDLNHHHHHH