abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	M	1 - 1	1
HFR1	QVQLVETGGGLVQAGGSLRLSCAASGSIFS	2 - 31	30
CDR-H1	LNAMG	32 - 36	5
HFR2	WFRQAPGKEREFVA	37 - 50	14
CDR-H2	TINRSGGRTYYADSVKG	51 - 67	17
HFR3	RFTISRDNGKNMVYLQMHSLKPEDTAIYYCAA	68 - 99	32
CDR-H3	GTGWSPQTDNEYNY	100 - 113	14
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	HHHHHH	124 - 130	6
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	AbM	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	Kabat	QVQLVETGGGLVQAGGSLRLSCAASGSIFS	2 - 31	30
	Contact	QVQLVETGGGLVQAGGSLRLSCAASGSIF-	2 - 30	29
	IMGT	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
CDR-H1	Chothia	GSIFSLN---	27 - 33	7
	AbM	GSIFSLNAMG	27 - 36	10
	Kabat	-----LNAMG	32 - 36	5
	Contact	----SLNAMG	31 - 36	6
	IMGT	GSIFSLNA--	27 - 34	8
HFR2	Chothia	AMGWFRQAPGKEREFVATI	34 - 52	19
	AbM	---WFRQAPGKEREFVA--	37 - 50	14
	Kabat	---WFRQAPGKEREFVA--	37 - 50	14
	Contact	---WFRQAPGKERE-----	37 - 47	11
	IMGT	-MGWFRQAPGKEREFVAT-	35 - 51	17
CDR-H2	Chothia	-----NRSGGR---------	53 - 58	6
	AbM	---TINRSGGRTY-------	51 - 60	10
	Kabat	---TINRSGGRTYYADSVKG	51 - 67	17
	Contact	FVATINRSGGRTY-------	48 - 60	13
	IMGT	----INRSGGRT--------	52 - 59	8
HFR3	Chothia	TYYADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYCAA	59 - 99	41
	AbM	--YADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYCAA	61 - 99	39
	Kabat	---------RFTISRDNGKNMVYLQMHSLKPEDTAIYYCAA	68 - 99	32
	Contact	--YADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYC--	61 - 97	37
	IMGT	-YYADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYC--	60 - 97	38
CDR-H3	Chothia	--GTGWSPQTDNEYNY	100 - 113	14
	AbM	--GTGWSPQTDNEYNY	100 - 113	14
	Kabat	--GTGWSPQTDNEYNY	100 - 113	14
	Contact	AAGTGWSPQTDNEYN-	98 - 112	15
	IMGT	AAGTGWSPQTDNEYNY	98 - 113	16
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	6ehg_C
Source	PDB 6ehg Submitted 13-SEP-2017 Updated 09-MAY-2018
Name	COMPLEMENT COMPONENT C3B IN COMPLEX WITH A NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	JENSEN K., PIHL R., GADEBERG F., JENSEN K., ANDERSEN R., THIEL S., LAURSEN S., ANDERSEN R. 'A POTENT COMPLEMENT FACTOR C3-SPECIFIC NANOBODY INHIBITING MULTIPLE FUNCTIONS IN THE ALTERNATIVE PATHWAY OF HUMAN AND MURINE COMPLEMENT.' J. BIOL. CHEM. V. 293 6269 2018 ESSN 1083-351X

Tools

Sequences

Amino Acid Sequence:

MQVQLVETGGGLVQAGGSLRLSCAASGSIFSLNAMGWFRQAPGKEREFVATINRSGGRTY
YADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYCAAGTGWSPQTDNEYNYWGQGTQV
TVSSHHHHHH