abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	G	1 - 1	1
HFR1	QVQLVQSGGGLVQAGGSLRLSCAFSGRTFS	2 - 31	30
CDR-H1	MYTMG	32 - 36	5
HFR2	WFRQAPGKEREFVA	37 - 50	14
CDR-H2	ANRGRGLSPDIADSVNG	51 - 67	17
HFR3	RFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	68 - 99	32
CDR-H3	DLQYGSSWPQRSSAEYDY	100 - 117	18
HFR4	WGQGTTVTVSS	118 - 128	11
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVQSGGGLVQAGGSLRLSCAFS-----	2 - 26	25
	AbM	QVQLVQSGGGLVQAGGSLRLSCAFS-----	2 - 26	25
	Kabat	QVQLVQSGGGLVQAGGSLRLSCAFSGRTFS	2 - 31	30
	Contact	QVQLVQSGGGLVQAGGSLRLSCAFSGRTF-	2 - 30	29
	IMGT	QVQLVQSGGGLVQAGGSLRLSCAFS-----	2 - 26	25
CDR-H1	Chothia	GRTFSMY---	27 - 33	7
	AbM	GRTFSMYTMG	27 - 36	10
	Kabat	-----MYTMG	32 - 36	5
	Contact	----SMYTMG	31 - 36	6
	IMGT	GRTFSMYT--	27 - 34	8
HFR2	Chothia	TMGWFRQAPGKEREFVAAN	34 - 52	19
	AbM	---WFRQAPGKEREFVA--	37 - 50	14
	Kabat	---WFRQAPGKEREFVA--	37 - 50	14
	Contact	---WFRQAPGKERE-----	37 - 47	11
	IMGT	-MGWFRQAPGKEREFVAA-	35 - 51	17
CDR-H2	Chothia	-----RGRGLS---------	53 - 58	6
	AbM	---ANRGRGLSPD-------	51 - 60	10
	Kabat	---ANRGRGLSPDIADSVNG	51 - 67	17
	Contact	FVAANRGRGLSPD-------	48 - 60	13
	IMGT	----NRGRGLSP--------	52 - 59	8
HFR3	Chothia	PDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	59 - 99	41
	AbM	--IADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	61 - 99	39
	Kabat	---------RFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	68 - 99	32
	Contact	--IADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYC--	61 - 97	37
	IMGT	-DIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--DLQYGSSWPQRSSAEYDY	100 - 117	18
	AbM	--DLQYGSSWPQRSSAEYDY	100 - 117	18
	Kabat	--DLQYGSSWPQRSSAEYDY	100 - 117	18
	Contact	AADLQYGSSWPQRSSAEYD-	98 - 116	19
	IMGT	AADLQYGSSWPQRSSAEYDY	98 - 117	20
HFR4	Chothia	-WGQGTTVTVSS	118 - 128	11
	AbM	-WGQGTTVTVSS	118 - 128	11
	Kabat	-WGQGTTVTVSS	118 - 128	11
	Contact	YWGQGTTVTVSS	117 - 128	12
	IMGT	-WGQGTTVTVSS	118 - 128	11

Accession & Annotations

Accession	6ezw_B
Source	PDB 6ezw Submitted 16-NOV-2017 Updated 28-NOV-2018
Name	CRYSTAL STRUCTURE OF A LLAMA VHH ANTIBODY BCD090-M2 AGAINST HUMAN ERBB3 IN SPACE GROUP C2
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 6f0d_A 6f0d_B
References	ELISEEV E., YUDENKO N., VYSOCHINSKAYA V., SVIRINA A., EVSTRATYEVA V., DROZHZHACHIH S., KRENDELEVA A., VLADIMIROVA K., NEMANKIN A., EKIMOVA M., ULITIN B., LOMOVSKAYA I., YAKOVLEV A., BUKATIN S., KNYAZEV A., MOISEENKO V., CHAKCHIR B. 'CRYSTAL STRUCTURES OF A LLAMA VHH ANTIBODY BCD090-M2 TARGETING HUMAN ERBB3 RECEPTOR.' F1000RES V. 7 57 2018 ISSN 2046-1402

Tools

Sequences

Amino Acid Sequence:

GQVQLVQSGGGLVQAGGSLRLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPD
IADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQ
GTTVTVSS