abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SYYMS	31 - 35	5
HFR2	WVRQAPGKGPEWVS	36 - 49	14
CDR-H2	GINTGGVGTRYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTALYYCAI	67 - 98	32
CDR-H3	GEGGNRNY	99 - 106	8
HFR4	WGQGTQVTVSS	107 - 117	11
Tail	HH	117 - 119	2
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSY---	26 - 32	7
	AbM	GFTFSSYYMS	26 - 35	10
	Kabat	-----SYYMS	31 - 35	5
	Contact	----SSYYMS	30 - 35	6
	IMGT	GFTFSSYY--	26 - 33	8
HFR2	Chothia	YMSWVRQAPGKGPEWVSGI	33 - 51	19
	AbM	---WVRQAPGKGPEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGPEWVS--	36 - 49	14
	Contact	---WVRQAPGKGPE-----	36 - 46	11
	IMGT	-MSWVRQAPGKGPEWVSG-	34 - 50	17
CDR-H2	Chothia	-----NTGGVG---------	52 - 57	6
	AbM	---GINTGGVGTR-------	50 - 59	10
	Kabat	---GINTGGVGTRYADSVKG	50 - 66	17
	Contact	WVSGINTGGVGTR-------	47 - 59	13
	IMGT	----INTGGVGT--------	51 - 58	8
HFR3	Chothia	TRYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTALYYCAI	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLKPEDTALYYCAI	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTALYYCAI	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLKPEDTALYYC--	60 - 96	37
	IMGT	-RYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTALYYC--	59 - 96	38
CDR-H3	Chothia	--GEGGNRNY	99 - 106	8
	AbM	--GEGGNRNY	99 - 106	8
	Kabat	--GEGGNRNY	99 - 106	8
	Contact	AIGEGGNRN-	97 - 105	9
	IMGT	AIGEGGNRNY	97 - 106	10
HFR4	Chothia	-WGQGTQVTVSS	107 - 117	11
	AbM	-WGQGTQVTVSS	107 - 117	11
	Kabat	-WGQGTQVTVSS	107 - 117	11
	Contact	YWGQGTQVTVSS	106 - 117	12
	IMGT	-WGQGTQVTVSS	107 - 117	11

Accession & Annotations

Accession	6fe4_H
Source	PDB 6fe4 Submitted 29-DEC-2017 Updated 14-MAR-2018
Name	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN SHIGA TOXIN STX2 B SUBUNIT AND NEUTRALISING NB113
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 6fe4_F 6fe4_G 6fe4_I 6fe4_J
References	BERNEDO-NAVARRO A., ROMAO E., YANO T., PINTO J., DE GREVE H., STERCKX G., MUYLDERMANS S. 'STRUCTURAL BASIS FOR THE SPECIFIC NEUTRALIZATION OF STX2A WITH A CAMELID SINGLE DOMAIN ANTIBODY FRAGMENT.' TOXINS (BASEL) V. 10 2018 ESSN 2072-6651

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYYMSWVRQAPGKGPEWVSGINTGGVGTRY
ADSVKGRFTISRDNAKNTLYLQMNSLKPEDTALYYCAIGEGGNRNYWGQGTQVTVSSHH