abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVQSGAELVKPGASVKMSCKASGYTFT	1 - 30	30
CDR-H1	SYNMH	31 - 35	5
HFR2	WVKQTPGQGLEWIG	36 - 49	14
CDR-H2	AIYPGNGDTSYNQKFKG	50 - 66	17
HFR3	KATLTADKSSSTAYMQLSSLTSEDSAVYYCAR	67 - 98	32
CDR-H3	AQLRPNYWYFDV	99 - 110	12
HFR4	WGAGTTVTVS	111 - 120	10
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVQSGAELVKPGASVKMSCKAS-----	1 - 25	25
	AbM	QVQLVQSGAELVKPGASVKMSCKAS-----	1 - 25	25
	Kabat	QVQLVQSGAELVKPGASVKMSCKASGYTFT	1 - 30	30
	Contact	QVQLVQSGAELVKPGASVKMSCKASGYTF-	1 - 29	29
	IMGT	QVQLVQSGAELVKPGASVKMSCKAS-----	1 - 25	25
CDR-H1	Chothia	GYTFTSY---	26 - 32	7
	AbM	GYTFTSYNMH	26 - 35	10
	Kabat	-----SYNMH	31 - 35	5
	Contact	----TSYNMH	30 - 35	6
	IMGT	GYTFTSYN--	26 - 33	8
HFR2	Chothia	NMHWVKQTPGQGLEWIGAI	33 - 51	19
	AbM	---WVKQTPGQGLEWIG--	36 - 49	14
	Kabat	---WVKQTPGQGLEWIG--	36 - 49	14
	Contact	---WVKQTPGQGLE-----	36 - 46	11
	IMGT	-MHWVKQTPGQGLEWIGA-	34 - 50	17
CDR-H2	Chothia	-----YPGNGD---------	52 - 57	6
	AbM	---AIYPGNGDTS-------	50 - 59	10
	Kabat	---AIYPGNGDTSYNQKFKG	50 - 66	17
	Contact	WIGAIYPGNGDTS-------	47 - 59	13
	IMGT	----IYPGNGDT--------	51 - 58	8
HFR3	Chothia	TSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCAR	58 - 98	41
	AbM	--YNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCAR	60 - 98	39
	Kabat	---------KATLTADKSSSTAYMQLSSLTSEDSAVYYCAR	67 - 98	32
	Contact	--YNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYC--	60 - 96	37
	IMGT	-SYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYC--	59 - 96	38
CDR-H3	Chothia	--AQLRPNYWYFDV	99 - 110	12
	AbM	--AQLRPNYWYFDV	99 - 110	12
	Kabat	--AQLRPNYWYFDV	99 - 110	12
	Contact	ARAQLRPNYWYFD-	97 - 109	13
	IMGT	ARAQLRPNYWYFDV	97 - 110	14
HFR4	Chothia	-WGAGTTVTVS	111 - 120	10
	AbM	-WGAGTTVTVS	111 - 120	10
	Kabat	-WGAGTTVTVS	111 - 120	10
	Contact	VWGAGTTVTVS	110 - 120	11
	IMGT	-WGAGTTVTVS	111 - 120	10

Accession & Annotations

Accession	AAG36946.1
Source	abYsis-EMBL-IG AF277091 Submitted 05-DEC-2000 Updated 05-DEC-2000
Name	murine B9E9 antibody heavy chain vh region
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Schultz J., Lin Y., Sanderson J., Zuo Y., Stone D., Mallett R., Wilbert S., Axworthy D. 'A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy' Cancer Res. 60(23):6663-6669(2000). Schultz J., Lin Y. Submitted (13-JUN-2000) to the INSDC. Molecular Biology, NeoRx Corp., 410 W Harrison St., Seattle, WA 98119, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVQSGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQGLEWIGAIYPGNGDTSY
NQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARAQLRPNYWYFDVWGAGTTVTVS

DNA Sequence:

caggttcagctggtccagtcaggggctgagctggtgaagcctggggcctcagtgaagatg
tcctgcaaggcttctggctacacatttaccagttacaatatgcactgggtaaagcagaca
cctggacagggcctggaatggattggagctatttatccaggaaatggtgatacttcctac
aatcagaagttcaaaggcaaggccacattgactgcagacaaatcctccagcacagcctac
atgcagctcagcagcctgacatctgaggactctgcggtctattactgtgcaagagcgcaa
ttacgacctaactactggtacttcgatgtctggggcgcagggaccacggtcaccgtgagc

Data Source:

Alignment settings:

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